93321-64-3Relevant academic research and scientific papers
The acetoxy protection of the benzopyranone compound preparation acetylenic ketone method
-
Page/Page column 0039-0042, (2017/08/19)
The invention discloses a method for preparing benzopyrone compounds through adopting acetoxy protected alkynyl ketone. The benzopyrone compounds are generated through a direct ring closure reaction of acetoxy protected alkynyl ketone at room temperature with piperazine as a catalyst. The method has the advantages of simple operation, no need of ligands, low price and small amount of the catalyst, stability of the catalyst to air and water, mild reaction conditions, short reaction time, low cost, high atom economy, extensive substrate applicability, and simple post-treatment and high yield of target products, and can be widely used to prepare natural products benzopyrone compounds.
A new series of flavones, thioflavones, and flavanones as selective monoamine oxidase-B inhibitors
Chimenti, Franco,Fioravanti, Rossella,Bolasco, Adriana,Chimenti, Paola,Secci, Daniela,Rossi, Francesca,Yá?ez, Matilde,Orallo, Francisco,Ortuso, Francesco,Alcaro, Stefano,Cirilli, Roberto,Ferretti, Rosella,Sanna, M. Luisa
experimental part, p. 1273 - 1279 (2010/04/24)
A new series of synthetic flavones, thioflavones, and flavanones has been synthesized and evaluated as potential inhibitors of monoamine oxidase isoforms (MAO-A and -B). The most active series is the flavanone one with higher selective inhibitory activity against MAO-B. Some of these flavanones (mainly the most effective) have been separated and tested as single enantiomers. In order to investigate the MAOs recognition of the most active and selective compounds, a molecular modeling study has been performed using available Protein Data Bank (PDB) structures as receptor models for docking experiments.
