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Upstream product

• 98-59-9 p-toluenesulfonyl chloride 
• 4224-87-7 4-methyl-chalcone 
• 6584-12-9 N-(diaminomethylidene)-4-toluenesulfonamide 
• 4224-96-8 3-phenyl-1-p-tolylprop-2-en-1-one 
• 59807-16-8 4-(4-methylphenyl)-6-phenylpyrimidin-2-amine 
• 100-52-7 benzaldehyde 

Relevant academic research and scientific papers

Tailored-design Synthesis of Sulfapyrimidine Derivatives

In this paper, we report an efficient and convenient approach for the synthesis of tailored-design target sulfapyrimidine derivatives expected to show remarkable antimicrobial activities. The approach is based on reacting arylsulfonyl guanidine with α,β-unsaturated carbonyl compounds to afford N-(4,6-diarylpyrimidin-2-yl)arylsulfonamide or with ylidene derivatives to afford N-(6-aryl-5-cyanopyrimidin-2-yl)arylsulfonamide, N-(4-amino-5-cyano-6-(methylthio)-pyrimidin-2-yl)-arylsulfonamide, and N-(5-cyanopyrimidin-2-yl)arylsulfonamide compounds through Michael addition reaction. The structure of the newly synthesized compounds was confirmed from spectral data and elemental analysis.

Synthesis, characterization, and anti-amoebic activity of N-(pyrimidin-2-yl)benzenesulfonamide derivatives

A new series of N-(pyrimidin-2-yl)benzenesulfonamide derivatives, 3a-3i and 4a-4i, was synthesized from pyrimidin-2-amines, 2a-2i, with the aim to explore their effects on in vitro growth of Entamoeba histolytica. The chemical structures of the compounds