93345-21-2

Upstream product

• 53250-82-1 p-(methylsulfonamido)aniline 
• 1197-22-4 N-phenylmethanesulfonamide 

Downstream Products

• 138490-79-6 4-[(methylsulfonyl)amino]-N-[2-(2-pyrimidinylamino)ethyl]benzenesulfonamide 
• 138490-58-1 N-<4-<<amino>sulfonyl>phenyl>methanesulfonamide methanesulfonate 
• 138490-57-0 2-phenyl>sulfonyl>amino>ethyl methanesulfonate 
• 138490-62-7 4-Methanesulfonylamino-N-{2-[methyl-(1-methyl-1H-benzoimidazol-2-yl)-amino]-ethyl}-benzenesulfonamide 
• 138490-53-6 WAY-123398 
• 138490-72-9 N-Methyl-N-[2-(2-methylamino-1H-benzimidazol-1-yl)ethyl]-4-[(methylsulfonyl)amino]benzenesulfonamide Hydrochloride 
• 138490-52-5 N-methyl-N-<2-ethyl>-4-<(methylsulfonyl)amino>benzenesulfonamide hydrochloride 
• 138490-74-1 N-methyl-N-<2-(methylqyinolin-2-ylamino)ethyl>-4-<(methylsulfonyl)amino>benzenesulfonamide hydrochloride 
• 138490-69-4 N-Methyl-N-[2-(2,3-dihydro-1H-imidazo[1,2-a]benzimidazol-1-yl)ethyl]4-[(methylsulfonyl)amino]benzenesulfonamide Hydrochloride 
• 120688-08-6 4-methylsulfonamido-N-(1-methylethyl)-N-[2-[(1-methylethyl)amino]ethyl]benzenesulfonamide 
• 120688-06-4 4-methylsulfonamido-N-[2-[bis(1-methylethyl)amino]ethyl]benzene sulfonamide 
• 116907-13-2 risotilide hydrochloride 
• 93345-23-4 C₁₃H₂₃N₂O₇PS₂ 

Relevant academic research and scientific papers

Identification of potent and selective small-molecule inhibitors of caspase-3 through the use of extended tethering and structure-based drug design

The design, synthesis, and in vitro activities of a series of potent and selective small-molecule inhibitors of caspase-3 are described. From extended tethering, a salicylic acid fragment was identified as having binding affinity for the S4 pocket of caspase-3. X-ray crystallography and molecular modeling of the initial tethering hit resulted in the synthesis of 4, which reversibly inhibited caspase-3 with a Ki = 40 nM. Further optimization led to the identification of a series of potent and selective inhibitors with Ki values in the 20-50 nM range. One of the most potent compounds in this series, 66b, inhibited caspase-3 with a Ki = 20 nM and selectivity of 8-500-fold for caspase-3 vs a panel of seven caspases (1, 2, and 4-8). A high-resolution X-ray cocrystal structure of 4 and 66b supports the predicted binding modes of our compounds with caspase-3.

Syntheses of N4-(Alkyl or arylsulfonyl)sulfanilyl Derivatives

2,4-Dichloro, 2,5-dichloro and 3,4-dichloro-benzene-sulfanilides react with chlorosulfonic acid at low temperature to give good yields of the corresponding dichlorobenzenesulfonyl sulfanilyl chlorides.A number of chlorides have been converted into derivatives by reaction with nucleophiles, such as dimethylamine, hydrazine and sodium azide.N4-Acetamidobenzenesulfonylsulfanilyl derivatives have been prepared by the condensation of N4-acetylsulfanilyl chloride with the appropriate sulfanilyl derivative.Methylsulfonanilide reacts with chlorosulfonic acid to give N4-(methylsulfonyl)sulfanilyl chloride.The compounds have been tested for their antibacterial and antifungal activity.