933469-68-2

Upstream product

• 40216-83-9 L-4-hydroxyproline methyl ester hydrochloride 
• 107-13-1 acrylonitrile 

Downstream Products

• 1613627-87-4 (8R,9aS)-8-[(5-cyclopropylpyrazin-2-yl)oxy]-2-{[3-(trifluoromethyl)phenyl]sulfonyl}octahydro-1H-pyrrolo[1,2-a][1,4]diazepane 
• 1613630-12-8 (8R,9aS)-8-[(triethylsilyl)oxy]-2-[3-(trifluoromethyl)phenyl]octahydro-1H-pyrrolo[1,2-a][1,4]diazepin-1-one 
• 1613630-11-7 (8R,9aS)-2-[3-fluoro-4-(trifluoromethyl)benzyl]-8-hydroxyoctahydro-1H-pyrrolo[1,2-a][1,4]diazepin-1-one 
• 1613628-11-7 (8R,9aS)-8-[(5-cyclopropylpyrazin-2-yl)oxy]-2-[3-fluoro-4-(trifluoromethyl)benzyl]octahydro-1H-pyrrolo[1,2-a][1,4]diazepin-1-one 
• 1613628-09-3 (8R,9aS)-8-[(5-cyclopropylpyrazin-2-yl)oxy]-2-[4-(trifluoromethyl)benzyl]octahydro-1H-pyrrolo[1,2-a][1,4]diazepin-1-one 
• 1613630-10-6 (8R,9aS)-8-hydroxy-2-[4-(trifluoromethyl)benzyl]octahydro-1H-pyrrolo[1,2-a][1,4]diazepin-1-one 
• 1613630-09-3 (8R,9aS)-8-[(triethylsilyl)oxy]-2-[4-(trifluoromethyl)benzyl]octahydro-1H-pyrrolo[1,2-a][1,4]diazepin-1-one 
• 1613628-08-2 (8R,9aS)-8-[(5-cyclopropylpyrazin-2-yl)oxy]-2-[3-(trifluoromethyl)benzyl]octahydro-1H-pyrrolo[1,2-a][1,4]diazepin-1-one 
• 1613630-08-2 (8R,9aS)-8-[(triethylsilyl)oxy]-2-[3-(trifluoromethyl)benzyl]octahydro-1H-pyrrolo[1,2-a][1,4]diazepin-1-one 

Relevant academic research and scientific papers

AGENTS FOR TREATING PAIN AND USES THEREOF

This invention relates to: (a) compounds and salts thereof that, inter alia, treat pain; (b) intermediates useful for the preparation of such compounds and salts; (c) compositions comprising such compounds and salts; (d) methods for preparing such intermediates, compounds, salts, and compositions; (e) methods of use of such compounds, salts, and compositions; and (f) kits comprising such compounds, salts, and compositions.

The diastereoselective synthesis of functionalised spirocyclic lactams and lactones using a Cope elimination/intramolecular nitrone cycloaddition strategy

Functionalised hydroxylamine derivatives of (S)-proline and pipecolic acid have been prepared using a Cope elimination. These hydroxylamines have been found to undergo oxidation to the nitrone either in the presence of air or a catalytic quantity of TPAP. An intramolecular 1,3-dipolar cycloaddition then occurs between the nitrone and pendant double bond to give tricyclic lactams and lactones with high diastereoselectivity.