933486-45-4

Usage

Uses

Used in Research Applications:
Methyl 4-hydroxyquinoline-6-carboxylate is used as a research chemical for [application reason], contributing to the development and understanding of quinolines and their derivatives.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, Methyl 4-hydroxyquinoline-6-carboxylate is used as a key intermediate in the synthesis of various pharmaceutical compounds for [application reason], such as the development of new drugs with potential therapeutic applications.
Used in Chemical Synthesis:
Methyl 4-hydroxyquinoline-6-carboxylate is used as a synthetic building block for [application reason], facilitating the creation of more complex organic compounds with diverse applications in various fields.

Upstream product

• 2033-24-1 cycl-isopropylidene malonate 
• 619-45-4 4-methoxycarbonyl aniline 
• 230631-82-0 5-(4-methoxycarbonylanilinomethylene)-2,2-dimethyl-1,3-dioxane-4,6-dione 

Downstream Products

• 219763-85-6 4-bromoquinoline-6-carboxylic acid methyl ester 
• 1264209-73-5 methyl 3-iodo-4-oxo-1,4-dihydroquinoline-6-carboxylate 

Relevant academic research and scientific papers

Cu(I)-Catalyzed Alkynylation of Quinolones

Herein we report the first alkynylation of quinolones with terminal alkynes under mild reaction conditions. The reaction is catalyzed by Cu(I) salts in the presence of a Lewis acid, which is essential for the reactivity of the system. The enantioselective version of this transformation has also been explored, and the methodology has been applied in the synthesis of the enantioenriched tetrahydroquinoline alkaloid cuspareine.

Direct C-3-alkenylation of quinolones via palladium-catalyzed C-H functionalization

An unprecedented C-3-alkenylation of quinolones was reported through palladium-catalyzed C-H functionalization with 1% catalyst loading. This method provides an efficient route to a variety of new quinolone derivatives.

Assembly of 4-aminoquinolines via palladium catalysis: A mild and convenient alternative to SNAr methodology

4-Aminoquinolines, classically prepared via SNAr chemistry from an amine and 4-haloquinoline, are important scaffolds in medicinal chemistry. Interest in these compounds prompted us to explore palladium catalysis as an alternative to the existing methods for their preparation. Initial results followed by an iterative screening paradigm confirmed Pd(OAc)2/ DPEphos/K3PO4 as a mild and convenient alternative for the formation of the C-N bond in 4-aminoquinolines. A description of the screen and the scope of this methodology are discussed herein.

QUINOLINE DERIVATIVES

The invention concerns quinoline derivatives of Formula (I): or a pharmaceutically-acceptable salt thereof, wherein each of X1, p, R1, q, R2, R3, R4, R5, Ring A, r and R6 has any of the meanings defined hereinbefore in the description; processes for their preparation, pharmaceutical compositions containing them and their use in the manufacture of a medicament for use in the treatment of cell proliferative disorders.