93351-55-4

Basic information

• Product Name: 1,3-Dioxane-4-methanol,2-phenyl-(9CI)
• Synonyms: 1,3-Dioxane-4-methanol,2-phenyl-(9CI)
• CAS NO: 93351-55-4
• Molecular Formula: C₁₁H₁₄O₃
• Molecular Weight: 194.22706
• Product Categories: PHENYL
• Mol File: 93351-55-4.mol
• Article Data: 13

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1,3-Dioxane-4-methanol,2-phenyl-(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 1,3-Dioxane-4-methanol,2-phenyl-(9CI)(93351-55-4)
• EPA Substance Registry System: 1,3-Dioxane-4-methanol,2-phenyl-(9CI)(93351-55-4)

Safety Data

• Hazardous Substances Data: 93351-55-4(Hazardous Substances Data)

Usage

General Description

1,3-Dioxane-4-methanol,2-phenyl-(9CI) is a chemical compound also known as 2-phenyl-1,3-dioxane-4-methanol. It is a type of phenyldioxane, which is a class of organic compounds containing a dioxane ring with a phenyl group attached to it. This particular compound is used in the synthesis of pharmaceuticals, fine chemicals, and agricultural products. It is also utilized as a solvent in various industrial applications. However, it is important to note that 1,3-Dioxane-4-methanol,2-phenyl-(9CI) has been identified as a potential environmental and health hazard, with concerns over its toxicity and persistence in the environment. Therefore, its usage and disposal should be carefully managed to minimize potential risks to human health and the environment.

Upstream product

• 1125-88-8 benzaldehyde dimethyl acetal 
• 70005-88-8 (R)-1,2,4-butanetriol 
• 3068-00-6 D,L-1,2,4-butanetriol 
• 100-52-7 benzaldehyde 
• 3969-69-5 (+/-)-cis-4-hydroxymethyl-2-phenyl-1,3-dioxolane 

Downstream Products

• 140210-14-6 (R,R)-4-(Acetoxymethyl)-2-phenyl-1,3-dioxane 
• 140210-14-6 (S,S)-4-(Acetoxymethyl)-2-phenyl-1,3-dioxane 
• 103773-79-1 [(2S,4S)-2-phenyl-1,3-dioxan-4-yl]methanol 
• 3969-69-5 (-)-cis-4-hydroxymethyl-2-phenyl-1,3-dioxolane 
• 1010702-34-7 C₁₂H₁₆O₅S 
• 102794-92-3 2-phenyl-1,3-dioxan-4-carbaldehyde 
• 1402820-10-3 C₁₂H₁₂O₂ 
• 602314-28-3 (Z)-3-((2R,4R)-2-Phenyl-[1,3]dioxan-4-yl)-acrylic acid methyl ester 
• 134665-70-6 (Z)-3-((2R,4R)-2-Phenyl-[1,3]dioxan-4-yl)-acrylic acid methyl ester 

Relevant articles and documents

Total Synthesis and Biological Evaluation of Siladenoserinol A and its Analogues

The total synthesis of siladenoserinol A, an inhibitor of the p53–Hdm2 interaction, has been achieved. AuCl3-catalyzed hydroalkoxylation of an alkynoate derivative smoothly and regioselectively proceeded to afford a bicycloketal in excellent yield. A glycerophosphocholine moiety was successfully introduced through the Horner–Wadsworth–Emmons reaction using an originally developed phosphonoacetate derivative. Finally, removal of the acid-labile protecting groups, followed by regioselective sulfamate formation of the serinol moiety afforded the desired siladenoserinol A, and benzoyl and desulfamated analogues were also successfully synthesized. Biological evaluation showed that the sulfamate is essential for biological activity, and modification of the acyl group on the bicycloketal can improve the inhibitory activity against the p53–Hdm2 interaction.

ANTIBACTERIAL AGENTS

Antibacterial compounds of formula (I) are provided, as well as stereoisomers and pharmaceutically acceptable salts thereof; pharmaceutical compositions comprising such compounds; methods of treating bacterial infections by the administration of such compounds; and processes for the preparation of such compounds.

Third-generation immucillins: Syntheses and bioactivities of acyclic immucillin inhibitors of human purine nucleoside phosphorylase

ImmH (1) and DADMe-ImmH (2) are potent inhibitors of human purine nucleoside phoshorylase (PNP), developed by us and currently in clinical trials for the treatment of a variety of T-cell related diseases. Compounds 1 and 2 were used as templates for the design and synthesis of a series of acyclic immucillin analogues (8-38) in order to identify simplified alternatives to 1 and 2. SerMe-ImmG (8) and DATMe- ImmG (9) displayed the lowest inhibition constants of 2.1 and 3.4 pM, respectively, vs PNP. It was postulated that the flexible natures of 8 and 9 enabled them to adopt conformations resembling those of 1 and 2 within the active site of PNP and that the positioning of two hydroxyl groups was critical for picomolar activity. SerMe-ImmH (10, K d = 5.2 pM) was shown to be orally available in mice with a long biological residence time on blood PNP.