93353-66-3

Usage

Methyl ester derivative

6-bromo-1-naphthoic acid The compound is derived from 6-bromo-1-naphthoic acid by replacing the carboxyl group (-COOH) with a methyl ester group (-COOCH3).

Class

Naphthalene carboxylic acids The compound belongs to the class of naphthalene carboxylic acids, which are organic compounds containing a naphthalene ring structure and a carboxylic acid group.

Appearance

Yellow to brown solid The compound has a yellow to brown color in its solid form.

Molecular weight

279.118 g/mol The molecular weight of the compound is 279.118 grams per mole, indicating the mass of a single molecule.

Uses

Organic synthesis, pharmaceuticals, agrochemicals, and dyes The compound is commonly used in various organic synthesis reactions and as an intermediate in the production of pharmaceuticals, agrochemicals, and dyes.

Potential applications

Materials science and organic electronic devices Due to its unique chemical properties and structural features, the compound has potential applications in the field of materials science and organic electronic devices.

Upstream product

• 67-56-1 methanol 
• 24050-49-5 3-bromonaphthalic-1,8-anhydride 
• 81-84-5 1,8-Naphthalic anhydride 

Downstream Products

• 106685-41-0 6-(3-adamantan-1-yl-4-methoxyphenyl)naphthalene-2-carboxylic acid methyl ester 
• 91804-22-7 6-Cyan-naphthoesaeure-(1)-methylester 

Relevant academic research and scientific papers

A new approach to rapid parallel development of four neurokinin antagonists. Part 2. Synthesis of ZD6021 cyano acid

The manufacture of ZD6021 cyano acid (1) using a new project approach is described. Research Department processes were scaled up to 100 L if process safety anal robustness were not compromised; other factors were treated according to the new approach. By using this strategy, we were able to manufacture a key intermediate on sufficient scale to support delivery of 1 kg quantities of bulk drug within 6 months of the start of lab work.

The mercury-mediated decarboxylation (Pesci reaction) of naphthoic anhydrides investigated by microwave synthesis

The mercury-mediated decarboxylation (Pesci reaction) of several substituted naphthoic anhydrides has been investigated by microwave synthesis. A laboratory microwave reactor was found to be ideal for small-scale preparations of this slow reaction, reducing reaction times from typically four days to less than 1 h for the three-step process. The ionic reaction medium rapidly heated to high temperatures under microwave heating and could be efficiently maintained by low microwave power settings. Generation of stoichiometric CO2 was safely contained within the reaction tubes. A simplified reaction procedure has been developed. For substituted naphthoic anhydrides, 1H NMR analysis of the naphthoate ester derivatives indicated no change in the regioisomer ratio compared to previously reported thermal values.