93363-19-0Relevant academic research and scientific papers
2-(3-pyridyl)thiazolidine-4-carboxamide derivatives. II. Structure- activity relationships and active configuration of 2-(3- pyridyl)thiazolidine-4-carboxamides as platelet-activating factor receptor antagonists
Suzuki, Takeshi,Nagaoka, Hitoshi,Kondo, Yutaka,Takahashi, Takumi,Takeuchi, Makoto,Hara, Hiromu,Saito, Munetoshi,Yamada, Toshimitsu,Tomioka, Kenichi,Hamada, Mamoru,Mase, Toshiyasu
, p. 1468 - 1473 (2007/10/03)
Conversion of the 2-(3-pyridyl)thiazolidine part of 1-(3-phenylpropyl)- 4-[2-(3-pyridyl)thiazolidine-4-carbonyl]piperazine (YM461), which is a potent platelet-activating factor (PAF) antagonist, to other rings was performed, and PAF antagonistic activitie
Platelet activating factor antagonists
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, (2008/06/13)
Indole compounds substituted at the 3-position by a 7-carbonyl(pyridin-3-yl)pyrrolo[1,2-c]thiazole, 7-carbonyl(pyridin-3-yl)pyrrolo[1,2-c]oxazole, or 7-carbonyl(pyridin-3-yl)pyrrolo[1,2-c]pyrrole group are potent antagionists of PAF and are useful in the treatment of PAF-related disorders including asthma, shock, respiratory distress syndrome, acute inflammation, transplanted organ rejection, gastrointesinal ulceration, allergic skin diseases, delayed cellular immunity, parturition, fetal lung maturation, and cellular differentiation.
Heterocyclic Compounds from Sugars, XV: On the Configuration of Chiral C-2 Substituted 1,3-Thiazolidine-4-carboxylic Acids. Chirality Transfer to C-3 of 3,4-Dihydro-1H-pyrrolothiazoles
Gyoergydeak, Z.,Szilagyi, L.,Kajtar, J.,Argay, G.,Kalman, A.
, p. 189 - 208 (2007/10/02)
5-Substituted 3,4-dihydro-pyrrolothiazole-6,7-dicarboxylic acid esters 3 are obtained from 2-substituted-3-acyl-1,3-thiazolidine-4-carboxylic acids, 1 in -cycloaddition reactions via mesoionic oxazolone ("muenchnone") intermediates.The chirali
Thiazolidinecarboxylic acid derivatives and treatment of liver diseases therewith
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, (2008/06/13)
The invention relates to novel thiazolidine-4(S)-carboxylic acid derivatives of the general formula (I) STR1 wherein R1 stands for an optionally substituted furyl, pyrrolyl, thienyl, benzofuryl, benzopyrrolyl, benzothienyl, phenyl, pyridyl, quinolinyl, isoquinolinyl or indanyl group or a C1-4 alkyl or C2-4 alkenyl group optionally substituted by a hydroxyl, carboxyl or halogen fenoxy group, stands for hydrogen, an alkaline metal or an alkaline earth metal atom or an optionally substituted C1-4 alkyl group or aryl group; R3 represents hydrogen or an optionally substituted C1-4 alkyl or acyl group or aryl group as well as their salts. Further on, the invention relates to pharmaceutical preparations containing these compounds and to a process for preparing these compounds and preparations. The compounds of the invention are useful for treating or preventing liver damages of either natural or experimental origin.
1H,3H-pyrrolo[1,2-c]thiazole derivatives having anti-allergic and anti-inflammatory activity
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, (2008/06/13)
New compounds of the formula STR1 in which R1 and R2 =H or alkyl and (a) R=CN or alkylcarbonyl, or (b) R=CON(R3)R4, in which R3 =H and R4 =NH2, alkylamino, dialkylamino, phenylam
