933721-99-4

Basic information

• Product Name: 6-Trifluoromethyl-pyrimidine-4-carboxylic acid
• Synonyms: 6-Trifluoromethyl-pyrimidine-4-carboxylic acid;6-(Trifluoromethyl)-4-pyrimidinecarboxylic acid
• CAS NO: 933721-99-4
• Molecular Formula: C6H3F3N2O2
• Molecular Weight: 192.1
• Mol File: 933721-99-4.mol

Chemical Properties

• Boiling Point: 294.4±40.0 °C(Predicted)
• Appearance: /
• Density: 1.575±0.06 g/cm3(Predicted)
• PKA: 2.38±0.10(Predicted)
• CAS DataBase Reference: 6-Trifluoromethyl-pyrimidine-4-carboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 6-Trifluoromethyl-pyrimidine-4-carboxylic acid(933721-99-4)
• EPA Substance Registry System: 6-Trifluoromethyl-pyrimidine-4-carboxylic acid(933721-99-4)

Safety Data

• Hazardous Substances Data: 933721-99-4(Hazardous Substances Data)

Upstream product

• 1353101-38-8 methyl 6-(trifluoromethyl)pyrimidine-4-carboxylate 
• 37552-81-1 4-chloro-6-(trifluoromethyl)pyrimidine 

Relevant articles and documents

KINASE INHIBITORS AND USES THEREOF

Provided are cyclic iminopyridimdine compounds and their bicyclic derivatives, pharmaceutical compositions comprising such compounds, and methods of using such compounds or compositions, such as methods of treating a proliferation disorder, such as a cancer or a tumor, or in some embodiments disease or disorders related to the dysregulation of kinase such as, but not limited to kinases such as MAPK, PDGFR, Src, PAKs, c-Kit, EphA2, EphB4, FGFR, Axl, and c-Met.

Spiro derivative, preparation method thereof and application of spiro derivative in medicine

The invention relates to a spiro derivative, a preparation method thereof and application of the spiro derivative in medicine. Specifically, the invention relates to the spiro derivative shown in a general formula (I), the preparation method thereof, a pharmaceutical composition containing the spiro derivative and application of the spiro derivative as a therapeutic agent, especially application of the spiro derivative as an RAF inhibitor and application of the spiro derivative in preparation of drugs for treating or preventing various diseases (including cancers) related to over-expression RAF activity.