93376-66-0Relevant academic research and scientific papers
Fabrication and characterization of dendrimer-encapsulated monometallic Co nanoparticles
Kavas,Durmus,Tanriverdi,?enel,Sozeri,Baykal
experimental part, p. 5341 - 5348 (2011/06/21)
A series of cobalt (Co) nanoparticles were synthesized by employing PAMAM dendrimers with different generations (G 0.0-3.0) as templates and sodium borohydride as a reducing agent. Extensive characterizations of the products were done using TEM, FT-IR, VSM, TGA, and XPS. The magnetization curves have superparamagnetic non hysteric characteristic at lower fields and with nonsaturation characteristic at high fields. All XRD patterns indicate that amorphous structure of all products. The shake-up satellites are observed at higher energies of the XPS peaks.
Evaluation of polyamidoamine (PAMAM) dendrimers as drug carriers of anti-bacterial drugs using sulfamethoxazole (SMZ) as a model drug
Ma, Minglu,Cheng, Yiyun,Xu, Zhenhua,Xu, Peng,Qu, Haiou,Fang, Yujie,Xu, Tongwen,Wen, Longping
, p. 93 - 98 (2007/10/03)
Sulfamethoxazole (SMZ), a sulfonamide with well-known anti-bacterial properties, is not freely soluble in water and causes problems in its clinical applications. In the present study we investigated the potential of ethylenediamine (EDA) core polyamidoamine (PAMAM) dendrimers as drug carriers of SMZ by aqueous solubility, in vitro release as well as anti-bacterial activity studies. Results showed that the aqueous solubility of SMZ was approximately proportional to dendrimer concentration (a 40-fold increase in solubility in 10 mg/ml G3 PAMAM dendrimer solutions compared with that in double-distilled water at 37 °C). The in vitro release of SMZ in the presence of PAMAM dendrimers was significantly slower compared to pure SMZ dissolved in ethanol. Microbiology studies showed that PAMAM dendrimers could increase the anti-bacterial activity of SMZ (a 4- or 8-fold increase in the anti-bacterial activity of SMZ in dendrimer solution compared to pure SMZ dissolved in dimethylsulfoxide (DMSO) or 0.01 M NaOH solution). The in vitro release behavior and anti-bacterial activity studies indicated that PAMAM dendrimers might be considered as potential drug carriers of sulfonamides with a sustained release behavior under suitable conditions.
Polyamidoamine (PAMAM) dendrimers as biocompatible carriers of quinolone antimicrobials: An in vitro study
Cheng, Yiyun,Qu, Haiou,Ma, Minglu,Xu, Zhenhua,Xu, Peng,Fang, Yujie,Xu, Tongwen
, p. 1032 - 1038 (2008/04/12)
Quinolones, an expanding class of clinically established potent antibiotics, is not freely soluble in water which prevents the design of liquid dosage forms and restricts their use in topical applications. In the present study we investigated the potential of polyamidoamine (PAMAM) dendrimers as drug carriers of quinolones (nadifloxacin and prulifloxacin) by aqueous solubility and antibacterial activity studies. Results showed that the aqueous solubility of nadifloxacin and prulifloxacin was significantly increased by PAMAM dendrimers. Microbiology studies showed that nadifloxacin and prulifloxacin still exhibit their strong antimicrobial activities in the presence of dendrimers. These studies indicated that PAMAM dendrimers might be considered as biocompatible carriers of quinolones under suitable conditions.
Solubility of nicotinic acid in polyamidoamine dendrimer solutions
Yiyun, Cheng,Tongwen, Xu
, p. 1384 - 1389 (2007/10/03)
In the present study we investigated the effect of ethylenediamine (EDA) core polyamidoamine (PAMAM) dendrimers on the aqueous solubility of nicotinic acid. The aqueous solubility of nicotinic acid was measured in the presence of dendrimers at room temperature in distilled water. The effect of variables, such as pH condition, concentration, surface functional group and generation (molecule size) of dendrimer, has been investigated. Results showed that the solubility of nicotinic acid in the dendrimer solutions was proportional to dendrimer concentration, both amine and ester-terminated dendrimers caused the higher increase in nicotinic acid solubility at higher pH conditions. The order in which the dendrimers increased the solubility at a constant pH condition was G4 > G3 > G2 > G1. In addition, at each pH, the solubility of nicotinic acid was greater in the presence of amine-terminated dendrimers compared to the amine ester-terminated dendrimers possessing the same number of surface functional groups. Under suitable conditions PAMAM dendrimers can be highly effective used to enhance the solubility of nicotinic acid.
Polyamidoamine dendrimers used as solubility enhancers of ketoprofen
Yiyun, Cheng,Tongwen, Xu,Rongqiang, Fu
, p. 1390 - 1393 (2007/10/03)
Ketoprofen is a non-steroidal anti-inflammatory drug which is not freely soluble in water and creates gastrointestinal problems. In the present study we investigated the potential of polyamidoamine (PAMAM) dendrimers to increase the solubility of ketoprofen. The effect of variables, such as pH condition, concentration and generation of dendrimer, has been investigated. The experimental results showed that the solubility of ketoprofen in the dendrimer solutions was proportional to dendrimer concentration. Under suitable conditions PAMAM dendrimers can be highly effective used to enhance the solubility of ketoprofen.
