93378-56-4

Basic information

• Product Name: 4-PHENYL-5-P-TOLYL-4H-[1,2,4]TRIAZOLE-3-THIOL
• Synonyms: AKOS BBS-00003293;5-(4-methylphenyl)-4-phenyl-2H-1,2,4-triazole-3-thione;BAS 01816560;EU-0036366;MLS000121764;SMR000119150;ZERO/006557;ZINC00311015
• CAS NO: 93378-56-4
• Molecular Formula: C₁₅H₁₃N₃S
• Molecular Weight: 267.35
• Mol File: 93378-56-4.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4-PHENYL-5-P-TOLYL-4H-[1,2,4]TRIAZOLE-3-THIOL(CAS DataBase Reference)
• NIST Chemistry Reference: 4-PHENYL-5-P-TOLYL-4H-[1,2,4]TRIAZOLE-3-THIOL(93378-56-4)
• EPA Substance Registry System: 4-PHENYL-5-P-TOLYL-4H-[1,2,4]TRIAZOLE-3-THIOL(93378-56-4)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 93378-56-4(Hazardous Substances Data)

Upstream product

• 103-72-0 phenyl isothiocyanate 
• 3619-22-5 p-toluic hydrazide 
• 104-87-0 4-methyl-benzaldehyde 
• 5351-69-9 4-Phenyl-3-thiosemicarbazide 
• 96134-00-8 C₁₁H₁₅N₃OS 
• 62-53-3 aniline 
• 103556-07-6 1-(p-methylbenzoyl)-4-phenyl-3-thiosemicarbazide 
• 43002-64-8 ethyl 4-methylbenzimidate hydrochloride 

Downstream Products

• 250334-26-0 C₄₁H₃₃N₃O₇S 
• 332922-94-8 2-{[5-(4-methylphenyl)-4-phenyl-4H-1,2,4-triazol-3-yl]thio}-1-phenylethanone 

Relevant articles and documents

Identification of 1,2,4-triazoles as new thymidine phosphorylase inhibitors: Future anti-tumor drugs

Thymidine phosphorylase (TP) is over expressed in several solid tumors and its inhibition can offer unique target suitable for drug discovery in cancer. A series of 1,2,4-triazoles 3a–3l has been synthesized in good yields and subsequently inhibitory potential of synthesized triazoles 3a–3l against thymidine phosphorylase enzyme was evaluated. Out of these twelve analogs five analogues 3b, 3c, 3f, 3l and 3l exhibited a good inhibitory potential against thymidine phosphorylase. Inhibitory potential in term of IC50 values were found in the range of 61.98 ± 0.43 to 273.43 ± 0.96 μM and 7-Deazaxanthine was taken as a standard inhibitor with IC50 = 38.68 ± 4.42 μM. Encouraged by these results, more analogues 1,2,4-triazole-3-mercaptocarboxylic acids 4a–4g were synthesized and their inhibitory potential against thymidine phosphorylase was evaluated. In this series, six analogues 4b–4g exhibited a good inhibitory potential in the range of 43.86 ± 1.11–163.43 ± 2.03 μM. Angiogenic response of 1,2,4-triazole acid 4d was estimated using the chick chorionic allantoic membrane (CAM) assay. In the light of these findings, structure activity relationship and molecular docking studies of selected triazoles to determine the key binding interactions was discussed. Docking studies demonstrate that synthesized analogues interacted with active site residues of thymidine phosphorylase enzyme through π-π stacking, thiolate and hydrogen bonding interactions.

Novel anthelmintic and insecticidal compositions

The present invention relates to novel anthelmintic and insecticidal compositions in general, and, more specifically, compositions containing triazole derivatives as active ingredients.