43002-64-8

Usage

Uses

Used in Pharmaceutical Research and Development:
ETHYL 4-METHYLBENZIMIDATE HYDROCHLORIDE is used as a key intermediate in the synthesis of various drugs and pharmaceuticals, contributing to the advancement of medicinal formulations due to its chemical properties and reactivity.
Used in Organic Synthesis:
In the field of organic synthesis, ETHYL 4-METHYLBENZIMIDATE HYDROCHLORIDE is utilized as a reagent to modify and synthesize a range of organic compounds, enhancing the scope of chemical production and innovation.
Used in Medicinal Chemistry:
ETHYL 4-METHYLBENZIMIDATE HYDROCHLORIDE is employed as a compound of interest in medicinal chemistry, where its biological activities and pharmacological properties are explored for potential therapeutic applications.

InChI:InChI=1/C10H13NO.ClH/c1-3-12-10(11)9-6-4-8(2)5-7-9;/h4-7,11H,3H2,1-2H3;1H

Upstream product

• 64-17-5 ethanol 
• 104-85-8 para-methylbenzonitrile 
• 75-36-5 acetyl chloride 

Downstream Products

• 104-84-7 para-methylbenzylamine 
• 99028-38-3 4-Methyl-N-(4-methylbenzoyl)benzimidsaeure-ethylester 
• 116204-79-6 N-benzyl-4-methylbenzenecarboximidamide hydrochloride salt 
• 181362-06-1 3-Benzyl-2-p-tolyl-3H-benzoimidazol-5-ol 
• 1103883-34-6 ethyl (S)-2-(4-methylphenyl)-4,5-dihydrooxazole-4-carboxylate 
• 6326-27-8 p-methylbenzamidine hydrochloride 
• 3005-30-9 3,5-bis(4-methylphenyl)-1H-1,2,4-triazole 
• 17583-92-5 4-methyl-6-(p-tolyl)-1,3,5-triazin-2-amine 
• 5599-21-3 2-Amino-4,6-di-(p-tolyl)-1,3,5-triazin 
• 1853-95-8 2-amino-4-phenyl-1,3,5-triazine 

Relevant academic research and scientific papers

DNA-Encoded Libraries: Hydrazide as a Pluripotent Precursor for On-DNA Synthesis of Various Azole Derivatives

DNA-encoded combinatorial chemical library (DEL) technology, an approach that combines the power of genetics and chemistry, has emerged as an invaluable tool in drug discovery. Skeletal diversity plays a fundamental importance in DEL applications, and relies heavily on novel DNA-compatible chemical reactions. We report herein a phylogenic chemical transformation strategy using DNA-conjugated benzoyl hydrazine as a common versatile precursor in azole chemical expansion of DELs. DNA-compatible reactions deriving from the common benzoyl hydrazine precursor showed excellent functional group tolerance with exceptional efficiency in the synthesis of various azoles, including oxadiazoles, thiadiazoles, and triazoles, under mild reaction conditions. The phylogenic chemical transformation strategy provides DELs a facile way to expand into various unique chemical spaces with privileged scaffolds and pharmacophores.

Colchicine derivatives, and preparation method and medical application thereof

The invention specifically relates to colchicine derivatives (I) as described in the specification and a preparation method thereof, and pharmaceutical compositions containing the colchicine derivatives, belonging to the field of medicinal chemistry. The results of pharmacodynamic experiments prove that the colchicine derivatives of the invention have treatment effect on lumbar disc herniation andliver fibrosis.

Synthesis of secondary amides from N-Substituted amidines by tandem oxidative rearrangement and isocyanate elimination

In this work an efficient tandem process transforming N-substituted amidines into secondary amides has been described. The process involves N-acylurea formation by reaction of the substrate with bis(acyloxy)(phenyl)-λ3-iodane followed by isocyanate elimination. The periodinane reagents are obtained from the commercially available phenyl-iodine(III) diacetate [PhI(OAc)2, (PIDA)] by ligand exchange with carboxylic acids. The N-substituted amidine substrates are easily synthesized from readily available nitriles. The method is applicable for secondary amide synthesis, based on both aliphatic and (hetero)aromatic amines, including challenging amides consisting of sterically hindered acids and amines. Moreover, the protocol allows one to combine steric bulk with electron deficiency in the target amides (aniline based). Such compounds are difficult to synthesize efficiently based on classical condensation reactions involving carboxylic acids and amines. Overall, the synthetic protocol transforms a nitrile into a secondary amide in both aliphatic and (hetero)aromatic systems.

Facile synthesis of 3,5-diaryl-1,2,4-triazoles via copper-catalyzed domino nucleophilic substitution/oxidative cyclization using amidines or imidates as substrates

Two methods for the synthesis of 3,5-diaryl-1,2,4-triazoles, both domino reactions, are reported. The first procedure, the Cu(OTf)2-catalyzed reaction between two amidines using NaHCO3 as a base, 1,10-phenanthroline as an additive and K3[Fe(CN)6]/ atmospheric oxygen as the oxidant, delivers 3,5-diaryl-1,2,4-triazoles with yields up to 68%. The second procedure for the synthesis of 3,5-diaryl-1,2,4- triazoles with yields up to 64% rests on the Cu(OTf)2-catalyzed reaction between two imidates and ammonium carbonate. This method features the formation of three bonds in a single synthetic step.

Synthesis and structure of aroylamidines and N-arylbenzamidines hydrochlorides

Aroylamidines can be obtained as salts in a reaction of the corresponding arylcarbonitriles with anhydrous ethanol in the presence of dry HCl followed by treating intermediate imidoesters with alcoholic solution of ammonia. N-Arylbenzamidines are obtained by reacting benzonitrile with arylamines in the presence of AlCl3. The structure of arylamines and the reaction conditions signifi cantly affect the yield of the target product, and sometimes the very possibility of its preparation. Pleiades Publishing, Ltd., 2012.

Syntheses, characterization and antimicrobial activity of some substituted 1,2,4-triazole derivatives

Syntheses of a series of 4-amino-3,5-dialkyl-1,2,4-triazoles are described. In present work, iminoester hydrochlorides (1) was treated with acyl hydrazines to obtain acylhydrazones (2). The compound acylhydrazones (2) converted to the 4-amino-3,5-dialkyl-

Reverse-benzamidine antimalarial agents: Design, synthesis, and biological evaluation

In the frame of the development of bis-cationic choline analogs, the RSA of bis-N-alkylamidines were studied and a new series of reverse-benzamidine derivatives was designed. Contrary to the lipophilicity, the basicity of alkylamidine compounds directly influences their antimalarial potencies.

Synthesis, structures of some unsymmetrical 3,6-disubstituted-1,2,4,5- tetrazines

(Chemical Equation Presented) A series of new unsymmetrical 3-phenyl-6-benzyl-1,2,4,5-tetrazine derivatives 10a-i were synthesized and characterized by IR, NMR, MS, and element analysis. The structures of 4a, 10c, 10d and 10h were analyzed by X-ray crystallography, which had intermolecular C-H...N, C-H...Cl, C-H...Π and Π...Π H interactions.

EPOTHILONE ANALOGUES MODIFIED AT POSITIONS C12-C13 AS ANTICANCER DRUGS

The invention relates to analogues of epothilones of formulae (A), (B), (I) and (II), uses and methods of making the same.

HETEROCYCLIC AMIDE COMPOUNDS AND PHARMACEUTICAL USE OF THE SAME

Heterocyclic amide compounds of the formula (I) STR1 wherein each symbol is as defined in the specification, pharmacologically acceptable salts thereof, pharmaceutical compositions thereof and pharmaceutical use thereof. The heterocyclic amide compounds and pharmacologically acceptable salts thereof of the present invention have superior inhibitory activity against chymase groups in mammals inclusive of human, and can be administered orally or parenterally. Therefore, they are useful as chymase inhibitors and can be effective for the prophylaxis and treatment of various diseases caused by chymase, such as those caused by angiotensin II.