93381-10-3Relevant academic research and scientific papers
Introduction of a chiral centre on C-6 of a carbohydrate unit: Application to the synthesis of the C-2 to C-15 fragment of ionomycin
Nicoll-Griffith,Weiler
, p. 2733 - 2750 (2007/10/02)
Glucose is converted into the α,β-unsaturated urono-8,4-lactone 29 using an intramolecular Wadsworth-Emmons reaction. Higher order cuprates add to the lactone to provide the C-6 substituted carbohydrate derivative with high stereoselectivity. This product can be converted into the dithiane 34b which when coupled with an appropriate epoxide yields compound 37 which contains the C-2 to C-15 fragment of ionomycin with the correct absolute stereochemistry at each asymmetric centre for conversion into ionomycin.
AN ENANTIOSELECTIVE SYNTHESIS OF THE C(10) TO C(23) BACKBONE OF THE POTENT IMMUNOSUPPRESSANT FK506
Smith III, Amos B.,Hale, Karl J.
, p. 1037 - 1040 (2007/10/02)
The C(10) to C(23) fragment of FK506 has been pepared in a convergent, highly stereocontrolled, fashion.The key transformations entailed opening of a symmetrical trans-disubstituted epoxide with a trisubstituted vinylalane ate complex, the reductive remov
1,1'-Thiocarbonyldi-2,2'-pyridone. A New Useful Reagent for Functional Group Conversions under Essentially Neutral Conditions
Kim, Sunggak,Yi, Kyu Yang
, p. 2613 - 2615 (2007/10/02)
1,1'-Thiocarbonyldi-2,2'-pyridone is a useful reagent for the preparation of nitriles, carbodiimides, cyclic thionocarbonates, and isothiocyanates and deoxygenation of alcohols under essentially neutral conditions.
