93382-53-7Relevant academic research and scientific papers
Proline-catalyzed one-step asymmetric synthesis of 5-hydroxy-(2E)-hexenal from acetaldehyde
Cordova, Armando,Notz, Wolfgang,Barbas III, Carlos F.
, p. 301 - 303 (2002)
For the first time, the L-proline-catalyzed direct asymmetric self-aldolization of acetaldehyde is described affording (+)-(5S)-hydroxy-(2E)-hexenal 2 with ee's ranging from 57 to 90%. Further transformations of 2 into synthetically valuable building bloc
