93392-00-8

Upstream product

• 90-02-8 salicylaldehyde 
• 78-93-3 butanone 
• 89-95-2 2-methyl-benzyl alcohol 
• 1629-58-9 4-penten-3-one 
• 108-95-2 phenol 

Downstream Products

• 104022-75-5 4,4a,5,6,7,8-Hexahydro-4-(2-hydroxyphenyl)-1,8-dimethyl-2(3H)-naphthalinon 
• 63755-77-1 3-(1-ethyl-2-methanesulfinyl-cyclopropylmethyl)-2,3-dihydro-benzofuran 
• 1353440-96-6 (E)-1-(2-(prop-2-ynyloxy)phenyl)pent-1-en-3-one 

Relevant academic research and scientific papers

Late-Stage Direct o-Alkenylation of Phenols by PdII-Catalyzed C?H Functionalization

o-Alkenylation of unprotected phenols has been developed by direct C?H functionalization catalyzed by PdII. This work features phenol group as a directing group and realizes highly site-selective C?H bond functionalization of phenols to achieve the corresponding products in moderate to excellent yields at 60 °C. The advantages of this reaction include unprecedented C?H functionalization using phenol as a directing group, high regioselectivity, good substrate scope, mild reaction conditions, and high efficiency. To the best of our knowledge, this is the first example of a regioselective C?H alkenylation of unprotected phenols utilizing phenolic hydroxyl group as a directing group. The alkenylation of unprotected tyrosine and intramolecular cyclization are also successfully carried out under this catalytic system in good yields. Furthermore, this novel method enables a late-stage modification of complex phenol-containing bioactive molecules toward a diversity-oriented drug discovery.

An atom-economical approach to the synthesis of potentially bioactive 2 H-chromenes via CuI-catalyzed reactions of Alkyl/Aryl-(E)-(o-propargyloxy)styryl ketones

A series of potentially bioactive 2H-chromenes have been synthesized in good yields (60-82%) via CuI-catalyzed reactions of alkyl/aryl-(E)-(o- propargyloxy)styryl ketones in an atom-economical approach. Georg Thieme Verlag Stuttgart · New York.

Tricyclic cyanoguanidines: Synthesis, site of action and insecticidal activity of a novel class of reversible acetylcholinesterase inhibitors

Bridged-tricyclic cyanoguanidines 1 were found to be active as insecticides. The preparation and structure-activity relationships of oxacyclic (X = O) and carbocyclic (X = CH2) analogues of 1 is described. Compounds 1 were found to inhibit acetylcholinesterase with IC50 values comparable to the organophosphate Paraoxon. Unlike organophosphates, cyanoguanidines 1 were shown to reversibly bind acetylcholinesterase. This mode of action is shared by the structurally-related natural product Huperzine A.