93398-05-1

Upstream product

• 110-91-8 morpholine 
• 7087-60-7 1-fluoro-3-methoxy-5-nitrobenzene 
• 79990-25-3 1-iodo-3-methoxy-5-nitro-benzene 

Downstream Products

• 1051899-52-5 3-morpholin-4-yl-5-nitro-phenol 
• 1051899-53-6 4-(3-nitro-5-phenylmethoxy-phenyl)morpholine 
• 1051899-54-7 3-morpholin-4-yl-5-phenylmethoxy-aniline 

Relevant academic research and scientific papers

Novel pazopanib derivatives and pharmaceutical composition comprising the same

The present invention relates to novel pazopanib derivatives or a salt thereof having inhibition activities of angiogenesis and epidermal growth factors at the same time, and to a pharmaceutical composition comprising the same as an active ingredient. The pazopanib derivatives have inhibition activities of angiogenesis and epidermal growth factors at the same time unlike pazopanib, thereby more effectively treating and preventing EGFR-related cancer diseases such as lung cancer, colon cancer or breast cancer through a multiple aim target, and effectively treating and preventing non-small-cell lung cancer which Iressa or Tarceva cannot have an effect on.COPYRIGHT KIPO 2017

NOVEL PYRIMIDINE DERIVATIVES 698

The invention concerns compounds of Formula (I), or a pharmaceutically acceptable salt thereof, where R1, n, R2, R3, and R4 are as defined in the description. The present invention also relates to processes for the preparation of such compounds, pharmaceutical compositions containing them and their use in the manufacture of a medicament for use as an antiproliferative agent in the prevention or treatment of tumours or other proliferative conditions which are sensitive to the inhibition of EphB4 kinases.