79990-25-3

Usage

Uses

Used in Pharmaceutical Industry:
1-iodo-3-Methoxy-5-nitrobenzene is used as an intermediate in the synthesis of various pharmaceuticals for its ability to be converted into more complex molecules with potential therapeutic properties.
Used in Organic Synthesis:
1-iodo-3-Methoxy-5-nitrobenzene is used as a building block in organic synthesis for its ability to be incorporated into more complex organic molecules, contributing to the development of new compounds with specific applications.
Used in Dye and Pigment Production:
1-iodo-3-Methoxy-5-nitrobenzene is used as a precursor in the production of dyes and pigments due to its chemical structure that can be modified to create a range of colors.
Used in Industrial Chemical Production:
1-iodo-3-Methoxy-5-nitrobenzene is used in the production of various industrial chemicals, taking advantage of its reactivity and functional groups to create compounds with specific properties for different applications.
Used as a Protecting Group in Organic Reactions:
The methoxy group in 1-iodo-3-Methoxy-5-nitrobenzene makes it useful as a protecting group in organic reactions, allowing chemists to temporarily mask functional groups during synthesis, ensuring selective reactions and protecting certain parts of the molecule from unwanted reactions.

Upstream product

• 586-10-7 3-methoxy-5-nitroaniline 
• 5327-44-6 3,5-dinitroanisole 
• 33844-21-2 2-nitro-4-methoxybenzoic acid 
• 98-95-3 nitrobenzene 
• 67-56-1 methanol 
• 6276-04-6 3,5-dinitroiodobenzene 
• 124-41-4 sodium methylate 

Downstream Products

• 1051899-53-6 4-(3-nitro-5-phenylmethoxy-phenyl)morpholine 
• 1051899-54-7 3-morpholin-4-yl-5-phenylmethoxy-aniline 
• 1051899-52-5 3-morpholin-4-yl-5-nitro-phenol 
• 861800-86-4 1-chloro-3-iodo-5-methoxybenzene 
• 1333950-32-5 C₉H₆ClNO 
• 1333950-30-3 C₂₂H₁₅ClN₆O 
• 1333950-16-5 C₂₃H₁₆ClN₅O 
• 1352622-34-4 C₁₆H₁₀ClN₃O 
• 1123157-82-3 3-(3-methoxy-5-nitrophenyl)thiophene 
• 93398-05-1 4-(3-methoxy-5-nitrophenyl)morpholine 
• 344324-66-9 1,3-diiodo-5-methoxybenzene 
• 269411-75-8 3-benzyloxy-5-iodo-benzamide 
• 269411-51-0 3-(3-carbamoyl-5-hydroxy-phenyl)-acrylic acid ethyl ester 
• 269411-74-7 3-hydroxy-5-iodo-benzamide 

Relevant academic research and scientific papers

Synthesis, Biological Evaluation, and Computational Analysis of Biaryl Side-Chain Analogs of Solithromycin

There is an urgent need for new antibiotics to mitigate the existential threat posed by antibiotic resistance. Within the ketolide class, solithromycin has emerged as one of the most promising candidates for further development. Crystallographic studies of bacterial ribosomes and ribosomal subunits complexed with solithromycin have shed light on the nature of molecular interactions (π-stacking and H-bonding) between from the biaryl side-chain of the drug and key residues in the 50S ribosomal subunit. We have designed and synthesized a library of solithromycin analogs to study their structure-activity relationships (SAR) in tandem with new computational studies. The biological activity of each analog was evaluated in terms of ribosomal affinity (Kd determined by fluorescence polarization), as well as minimum inhibitory concentration assays (MICs). Density functional theory (DFT) studies of a simple binding site model identify key H-bonding interactions that modulate the potency of solithromycin analogs.

Pd-Catalyzed Decarboxylative Ortho-Halogenation of Aryl Carboxylic Acids with Sodium Halide NaX Using Carboxyl as a Traceless Directing Group

A highly regioselective Pd-catalyzed carboxyl directed decarboxylative ortho-C-H halogenation of cheap o-nitrobenzoic acids with NaX (X = I, Br) under aerobic conditions has been established. The utility of the method has been demonstrated by the gram-scale reaction and derivatization of the product. Experimental results have confirmed Pd and Bi played critical roles in the transformation and indicated the transformation might proceed via 2-halo-6-nitrobenzoic acid derivative intermediate.

Efficient discovery of potent anti-HIV agents targeting the Tyr181Cys variant of HIV reverse transcriptase

Non-nucleoside reverse transcriptase inhibitors (NNRTIs) that interfere with the replication of human immunodeficiency virus (HIV) are being pursued with guidance from molecular modeling including free-energy perturbation (FEP) calculations for protein-in

Discovery of novel and potent leukotriene B4 receptor antagonists. Part 1

The inhibition of LTB4 binding to and activation of G-protein-coupled receptors BLT1 and BLT2 is the premise of a treatment for several inflammatory diseases. In a lead optimization effort starting with the leukotriene B4 (LTB4

Leukotriene B4 Inhibitors

Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of diseases such as, for example, COPD

Substituted benzamide inhibitors of rhinovirus 3C protease

Nonpeptide benzamide-containing inhibitors of human rhinovirus (HRV) 3C protease are described.

Benzothiazole derivatives with activity as adenosine receptor ligands

The present invention relates to substituted benzothiazole derivitives and to their pharmaceutically acceptable salts useful for the treatment of diseases related to the adenosine receptor.

Substituted benzamide inhibitors of human rhinovirus 3C protease: Structure-based design, synthesis, and biological evaluation

A series of nonpeptide benzamide-containing inhibitors of human rhinovirus (HRV) 3C protease was identified using structure-based design. The design, synthesis, and biological evaluation of these inhibitors are reported. A Michael acceptor was combined with a benzamide core mimicking the P1 recognition element of the natural 3CP substrate, α,β-Unsaturated cinnamate esters irreversibly inhibited the 3CP and displayed antiviral activity (EC50 0.60/μM, HRV-16 infected H1-HeLa cells). On the basis of cocrystal structure information, a library of substituted benzamide derivatives was prepared using parallel synthesis on solid support. A 1.9 A? cocrystal structure of a benzamide inhibitor in complex with the 3CP revealed a binding mode similar to that initially modeled wherein covalent attachment of the nucleophilic cysteine residue is observed. Unsaturated ketones displayed potent reversible inhibition but were inactive in the cellular antiviral assay and were found to react with nucleophilic thiols such as DTT.

Synthesis of Unlabelled and Carboxyl-Labelled 3-Amino-5-hydroxybenzoic Acid

Efficient syntheses are reported of the natural amino acid 3-amino-5-hydroxybenzoic acid in unlabelled and carboxyl-labelled forms from 3,5-dinitrobenzoic acid and 3,5-dinitroanisole, respectively.