933981-53-4Relevant academic research and scientific papers
Amino acid-based enantiomerically pure 3-substituted 1,4-benzodiazepin-2-ones: A new class of anti-ischemic agents
Mishra, Jitendra Kumar,Garg, Puja,Dohare, Preeti,Kumar, Ashutosh,Siddiqi, Mohammad Imran,Ray, Madhur,Panda, Gautam
, p. 1326 - 1331 (2007/10/03)
A series of 3-substituted 1, 4-benzodiazepin-2-ones derived from S and R amino acids were evaluated for their anti-ischemic activity in vitro. Treatment with compounds 7h, 16, 9d, and 17 decreased the apoptotic neuronal number, however increased the neuronal viability. The compounds decreasing apoptosis could protect neurons from the ischemic injury. The difference in the activities of 1,4-benzodiazepin-2-ones derived from S- and R-amino acids is discussed and explained on the basis of molecular modeling studies.
