933986-41-5Relevant academic research and scientific papers
Design and synthesis of (E)-1,2-diphenylethene-based EZH2 inhibitors
Feng, Qiang,Feng, Zhanzhan,He, Hualong,Hu, Xi,Liu, Zhihao,Teng, Fei,Yu, Luoting,Zhang, Qiangsheng
, (2020)
Enhancer of zeste homolog 2 (EZH2) serves as the catalytic subunit of the polycomb repression complex 2 (PRC2), which is implicated in cancer progression metastasis and poor prognosis. Based on our EZH2 inhibitor SKLB1049 with low nanomolar activity, we e
Selective and efficient synthesis of trans-arylvinylboronates and trans-hetarylvinylboronates using palladium catalyzed cross-coupling
Liu, Zhihao,Wei, Wei,Xiong, Lu,Feng, Qiang,Shi, Yaojie,Wang, Ningyu,Yu, Luoting
supporting information, p. 3172 - 3176 (2017/04/14)
trans-Arylvinylboronate derivatives are important synthesis blocks in natural products, pharmaceuticals and organic materials. There are only a few reaction conditions that could selectively provide trans-arylvinylboronates by Heck coupling of pinacol vin
