934-33-8 Usage
Uses
Used in Pharmaceutical Research and Development:
1H-Purine, 8-methyl(9CI) is used as a key intermediate in the synthesis of various purine-based compounds for potential pharmaceutical applications. Its unique structure and methylation at the 8-position allow for the development of novel therapeutic agents with specific biological activities.
Used in Drug Synthesis:
1H-Purine, 8-methyl(9CI) is utilized as a building block in the creation of new drugs, particularly those targeting adenosine receptors or involved in the regulation of cellular processes. Its presence in the synthesized compounds can modulate their interaction with biological targets, leading to the discovery of new therapeutic agents with improved efficacy and selectivity.
Used in Biochemical Studies:
1H-Purine, 8-methyl(9CI) is employed in biochemical research to investigate the role of purines in various biological processes, such as signal transduction, energy metabolism, and nucleic acid synthesis. Its unique structure allows researchers to probe the interactions between purine-based compounds and their target molecules, providing insights into the molecular mechanisms underlying their biological activities.
Check Digit Verification of cas no
The CAS Registry Mumber 934-33-8 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 9,3 and 4 respectively; the second part has 2 digits, 3 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 934-33:
(5*9)+(4*3)+(3*4)+(2*3)+(1*3)=78
78 % 10 = 8
So 934-33-8 is a valid CAS Registry Number.
InChI:InChI=1/C6H6N4/c1-4-9-5-2-7-3-8-6(5)10-4/h2-3H,1H3,(H,7,8,9,10)
934-33-8Relevant articles and documents
Mechanisms for the Solvolytic Decompositions of Nucleoside Analogues. IX. Pathways for the Alkyline Hydrolysis of 6-Substituted 9-(1-Ethoxyethyl)purines
Loennberg, Harri,Lehikoinen, Pertti,Neuvonen, Kari
, p. 707 - 712 (2007/10/02)
A few 6-substituted 9-(1-ethoxyethyl)purines have been prepared and the rates of their base-catalyzed hydrolysis were measured by UV spectroscopy.The product mixtures were fractionated by preparative TLC and characterized by NMR and UV spectroscopy.The results obtained suggest that the alkaline cleavage of 9-(1-ethoxyethyl)purines generally proceeds by nucleophilic attack of hydroxide ion on C8 of the purine moiety, resulting in formation of appropriate 4,5-diaminopyrimidine and 8-methylpurine as final products.With 6-methoxy, 6-methylthio, and 6-chloro derivatives nucleophilic attack of hydroxide ion of C6 giving 9-(1-ethoxyethyl)hypoxanthine competes with this reaction.
