93422-80-1Relevant articles and documents
A convenient synthetic method of isoxazole derivatives using copper(II) nitrate
Itoh, Ken-Ichi,Aoyama, Tadashi,Satoh, Hiroaki,Hasegawa, Kenta,Meguro, Natsumi,Horiuchi, Akira C.,Takido, Toshio,Kodomari, Mitsuo
, p. 1473 - 1482 (2014/07/07)
3-Acetylisoxazoles were synthesized by the reaction of alkenes or alkynes in acetone as solvent with copper(II) nitrate and formic acid. In the case of ethyl acetate as solvent, 3-benzoylisoxazoles were yielded by the reaction of alkynes and acetophenone
AMINOTRIAZOLE DERIVATIVES AS ALX AGONISTS
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Page/Page column 89-90, (2009/07/18)
The invention relates to aminotriazole derivatives of formula (I), wherein A, E, R1 and R2 are as defined in the description, their preparation and their use as pharmaceutically active compounds. The compounds are useful for the prevention or treatment of diseases, which respond to the modulation of the ALX receptor such as inflammatory diseases.
Synthesis and pharmacological investigation of cholinergic ligands structurally related to muscarone
de Amici, Marco,de Micheli, Carlo,Grana, Enzo,Rodi, Roberto,Zonta, Franco,Santagostino-Barbone, Maria Grazia
, p. 171 - 178 (2007/10/02)
Five new analogs of muscarone were synthesized in order to evulate the influence of the carbonyl group on muscarinic activity.We chose to introduce structural variations at the C-2 and C-3 positions of the tetrahydrofuran ring.The muscarinic activity was evaluated in vitro on guinea pig atria and ileum as well as on rat jejunum and urinary bladder.All the new derivatives are less potent than muscarone and three of them displayed a potency very close to that previously reported for muscarine.The tissue selectivity observed for the 3-methylene derivative which is eight times more potent on guinea pig ileum than atria is worth noting.The present data show the lack of a simple relationship between the polarity of the group located in the 3-position of the ring and the muscarinic activity.
