934220-94-7

Basic information

• Product Name: N-(N-benzoyl-4-nitro-L-phenylalanyl)-L-phenylalaninol
• Synonyms: N-(N-benzoyl-4-nitro-L-phenylalanyl)-L-phenylalaninol
• CAS NO: 934220-94-7
• Molecular Weight: 447.491
• Mol File: 934220-94-7.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: N-(N-benzoyl-4-nitro-L-phenylalanyl)-L-phenylalaninol(CAS DataBase Reference)
• NIST Chemistry Reference: N-(N-benzoyl-4-nitro-L-phenylalanyl)-L-phenylalaninol(934220-94-7)
• EPA Substance Registry System: N-(N-benzoyl-4-nitro-L-phenylalanyl)-L-phenylalaninol(934220-94-7)

Safety Data

• Hazardous Substances Data: 934220-94-7(Hazardous Substances Data)

Upstream product

• 65-85-0 benzoic acid 
• 81677-60-3 (L)-p-Nitrophenylalanine methyl ester 
• 3182-95-4 L-Phenylalaninol 
• 69935-12-2 (S)-4-nitro-N-benzoyl-phenylalanine 

Downstream Products

• 934221-94-0 N-(N-benzoyl-4-amino-L-phenylalanyl)-L-phenylalaninol 

Relevant articles and documents

Synthesis and anti-tumor activity evaluation of Matijin-Su derivatives

A series of Matijin-Su (MTS, N-(N-benzoyl-l-phenylalanyl)-O-acetyl-l- phenylalanol) derivatives was synthesized and evaluated for their anti-tumor activities in hepatocellular carcinoma cells. The IC50 of compounds 1, 3, 4, 11, 13 were less than 20 μM, and compound 1 and 3 showed an IC 50 value of less than 9 μM. Expansion inhibition could be found significantly in compound 1 and 3-treated human hepatoma cell HepG2 and PLC/PRF/5, while both compounds exhibit lower toxicity to human hepatocyte cell line L-02. Compound 1 and 3 could induce cell cycle arrest at G1/S phase. This may be attributed to increase level of intracellular reactive oxygen species (ROS). Up-regulation of p38 MAPK activity in responding the ROS stabilize p53 and activate p21 transcription, the critical regulatory in G1/S checkpoint. Observations in this study shed light on the potential of MTS derivatives compound 1 and 3 as novel suppressors to human liver cancer.

Synthesis and anti-hepatitis B virus activities of Matijing-Su derivatives

A series of derivatives of Matijing-Su (MTS, N-(N-benzoyl-l-phenylalanyl)-O-acetyl-l-phenylalanol) was synthesized and evaluated for their anti-hepatitis B virus (HBV) activities in 2.2.15 cells. The IC50 of compounds 9c (1.40 μM), 9g (2.33 μM) and 9n (2.36 μM), etc. and the selective index of 9n (45.93) of the inhibition on the replication of HBV DNA were higher than those of the positive control lamivudine [41.59, (IC50: 82.42 μM)]. Compounds 11d, 12a and 12e also exhibited significant anti-HBV activities.