934221-02-0

Basic information

• Product Name: N-(N-benzoyl-4-nitro-L-phenylalanyl)-L-tyrosine methyl ester
• CAS NO: 934221-02-0
• Molecular Weight: 491.5
• Mol File: 934221-02-0.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: N-(N-benzoyl-4-nitro-L-phenylalanyl)-L-tyrosine methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: N-(N-benzoyl-4-nitro-L-phenylalanyl)-L-tyrosine methyl ester(934221-02-0)
• EPA Substance Registry System: N-(N-benzoyl-4-nitro-L-phenylalanyl)-L-tyrosine methyl ester(934221-02-0)

Safety Data

• Hazardous Substances Data: 934221-02-0(Hazardous Substances Data)

Upstream product

• 65-85-0 benzoic acid 
• 81677-60-3 (L)-p-Nitrophenylalanine methyl ester 
• 69935-12-2 (S)-4-nitro-N-benzoyl-phenylalanine 
• 3417-91-2 L-tyrosine methyl ester HCl 

Relevant articles and documents

Synthesis and anti-tumor activity evaluation of Matijin-Su derivatives

A series of Matijin-Su (MTS, N-(N-benzoyl-l-phenylalanyl)-O-acetyl-l- phenylalanol) derivatives was synthesized and evaluated for their anti-tumor activities in hepatocellular carcinoma cells. The IC50 of compounds 1, 3, 4, 11, 13 were less than 20 μM, and compound 1 and 3 showed an IC 50 value of less than 9 μM. Expansion inhibition could be found significantly in compound 1 and 3-treated human hepatoma cell HepG2 and PLC/PRF/5, while both compounds exhibit lower toxicity to human hepatocyte cell line L-02. Compound 1 and 3 could induce cell cycle arrest at G1/S phase. This may be attributed to increase level of intracellular reactive oxygen species (ROS). Up-regulation of p38 MAPK activity in responding the ROS stabilize p53 and activate p21 transcription, the critical regulatory in G1/S checkpoint. Observations in this study shed light on the potential of MTS derivatives compound 1 and 3 as novel suppressors to human liver cancer.