934340-38-2

Basic information

• Product Name: C₁₅H₁₄ClNO₅
• CAS NO: 934340-38-2
• Molecular Weight: 323.733
• Mol File: 934340-38-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₁₅H₁₄ClNO₅(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₅H₁₄ClNO₅(934340-38-2)
• EPA Substance Registry System: C₁₅H₁₄ClNO₅(934340-38-2)

Safety Data

• Hazardous Substances Data: 934340-38-2(Hazardous Substances Data)

Upstream product

• 111841-05-5 2-bromo-1-(5-chloro-2-methoxyphenyl)-ethanone 
• 69316-10-5 3-(5-chloro-2-methoxyphenyl)-3-oxopropanenitrile 
• 6342-64-9 2-methoxy-5-chloroacetophenone 
• 934340-26-8 C₁₃H₁₂ClNO₄ 
• 108-24-7 acetic anhydride 

Downstream Products

• 934340-41-7 C₁₆H₁₆ClNO₅ 

Relevant articles and documents

3-Substituted-(5-arylfuran-2-ylcarbonyl)guanidines as NHE-1 inhibitors

The C-3 substituents effect on NHE-1 inhibitory activity of (5-arylfuran-2-ylcarbonyl)guanidines, previously identified as potent NHE-1 inhibitors, was investigated. The introduction of amine or alkyl groups at the 3-position of the furan ring, next to the acylguanidine moiety, remarkably improves NHE-1 inhibitory potency. Especially the important finding is that 5-(2,5-dichloro)phenyl and 5-(2-methoxy-5-chloro)phenyl derivatives exhibit high NHE-1 inhibitory activities (IC50 0.02 μM) that match those of 3-unsubstituted derivatives.