934355-64-3

Upstream product

• 934355-51-8 4-(2-bromobenzyl)-1,2,3,4-tetrahydrobenzo[f]isoquinoline 
• 24424-99-5 di-tert-butyl dicarbonate 
• 934355-43-8 2-(2-bromophenyl)-N-[2-(naphth-1-yl)ethyl]acetamide 
• 18698-97-0 ortho-bromophenylacetic acid 
• 55116-09-1 2-bromophenylacetyl chloride 

Relevant academic research and scientific papers

Aporphine alkaloid synthesis and diversification via direct arylation

Palladium-catalyzed direct arylation of aryl chlorides, bromides and iodides has been applied to the preparation of new aporphine analogues including C2-substituted aporphines by reaction with benzodioxole, pyridine N-oxide and pyrazine N-oxide. Successful application of direct arylation in these diversification reactions highlights its utility not only in convergent, but also in divergent synthesis. We also describe enantioselective syntheses of (R)-nornuciferine and (R)-nuciferine employing a catalytic asymmetric transfer hydrogenation in high yield and excellent enantiomeric excess. Wiley-VCH Verlag GmbH & Co. KGaA, 2007.