934384-85-7

Upstream product

• 1039750-61-2 (S,E)-N-(2-bromo-4-fluorobenzylidene)-2-methylpropane-2-sulfinamide 
• 105-36-2 ethyl bromoacetate 
• 1206806-06-5 C₂₇H₂₉BrFNO₃ 

Downstream Products

• 1206808-13-0 C₁₉H₂₈BrFN₂O₄ 
• 934346-18-6 (β-R)-ethyl β-amino-2-bromo-4-fluorobenzenepropanoate hydrochloride 
• 1177369-29-7 (R)-ethyl 3-(2-bromo-4-fluorophenyl)-3-(3-oxobutanamido)propanoate 

Relevant academic research and scientific papers

OXIM DERIVATIVES AS HSP90 INHIBITORS

The invention relates to HSP90 inhibiting compounds consisting of the formula: (I) wherein the variables are as defined herein. The invention also relates to pharmaceutical compositions, kits and articles of manufacture comprising such compounds; methods and intermediates useful for making the compounds; and methods of using said compounds.

2-AMINO-7,8-DIHYDRO-6H-PYRIDO[4,3-D] PYRIMIDIN-5-ONES

Disclosed are 2-amino-7,8-dihydro-6H-pyrido[4,3-d]pyrimidin-5-one compounds, their stereoisomers, tautomers, pharmaceutically acceptable salts, and prodrugs thereof; compositions that include a pharmaceutically acceptable carrier and one or more of the 2-amino-7,8-dihydro-6H-pyrido[4,3-d]pyrimidin-5-one compounds, either alone or in combination with at least one additional therapeutic agent. Disclosed also are methods of using the 2-amino-7,8-dihydro-6H-pyrido[4,3-d]pyrimidin-5-one compounds, either alone or in combination with at least one additional therapeutic agent, in the prophylaxis or treatment of cellular proliferative, viral, autoimmune, cardiovascular, and central nevous system diseases.