934470-34-5

Basic information

• Product Name: methyl 2-{3-cyano-4-[1-(triisopropylsilyl)-1H-pyrrol-3-yl]phenyl}isonicotinate
• Synonyms: methyl 2-{3-cyano-4-[1-(triisopropylsilyl)-1H-pyrrol-3-yl]phenyl}isonicotinate
• CAS NO: 934470-34-5
• Molecular Weight: 459.663
• Mol File: 934470-34-5.mol

Chemical Properties

• CAS DataBase Reference: methyl 2-{3-cyano-4-[1-(triisopropylsilyl)-1H-pyrrol-3-yl]phenyl}isonicotinate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 2-{3-cyano-4-[1-(triisopropylsilyl)-1H-pyrrol-3-yl]phenyl}isonicotinate(934470-34-5)
• EPA Substance Registry System: methyl 2-{3-cyano-4-[1-(triisopropylsilyl)-1H-pyrrol-3-yl]phenyl}isonicotinate(934470-34-5)

Safety Data

• Hazardous Substances Data: 934470-34-5(Hazardous Substances Data)

Upstream product

• 40530-18-5 5-bromo-2-hydroxybenzonitrile 
• 876919-06-1 2-[4-(benzyloxy)-3-cyanophenyl]isonicotinic acid methyl ester 
• 876918-34-2 2-(3-cyano-4-hydroxyphenyl)isonicotinic acid methyl ester 
• 835898-37-8 1-(benzyloxy)-4-bromo-2-cyanobenzene 
• 876918-46-6 2-(3-cyano-4-{[(trifluoromethyl)sulfonyl]oxy}phenyl)isonicotinic acid methyl ester 
• 138900-55-7 1-(triisopropylsilyl)-1H-pyrrole-3-boronic acid 

Downstream Products

• 934470-35-6 methyl 2-[3-cyano-4-(1H-pyrrol-3-yl)phenyl]isonicotinate 
• 934468-60-7 2-[3-cyano-4-(1H-pyrrol-3-yl)phenyl]isonicotinic acid 

Relevant articles and documents

REMEDY OR PREVENTIVE FOR DIGESTIVE ULCER

An object of the present invention is to provide an agent for treating or preventing digestive ulcer that is effective even to ulcer of small intestine and others, for which gastric acid secretion inhibitors such as proton pump inhibitors are ineffective, and is superior to allopurinol in the efficaciousness and the safety. The pharmaceutical composition of the present invention comprising a non-purine xanthine oxidase inhibitor as the active ingredient is useful as an agent for treating or preventing ulcer that forms in digestive tracts by the attack of gastric acid, pepsin, stress, Helicobacter pylori bacteria, NSAID, etc. In particular, it is useful as an ulcer remedy heretofore unknown in the art as it is effective even for ulcer in small intestine for which gastric/duodenal ulcer remedies that inhibit gastric acid secretion such as proton pump inhibitors are ineffective.

TRIARYLCARBOXYLIC ACID DERIVATIVE

It is intended to provide an agent for treating or preventing hyperuricemia, gout, inflammatory bowel disease, diabetic nephropathy, diabetic retinopathy and so on which has a non-nucleic acid structure and exerts an excellent xanthine oxidase inhibiting action and a hypouricemic effect. It has been confirmed that a novel triarylcarboxylic acid derivative, which is characterized by having a carboxyl-substituted heteroaryl group and an aromatic ring group such as a phenyl group attached in para-position on a benzene ring and further carrying a cyano group on the same benzene ring, has a potent xanthine oxidase inhibiting action and a hypouricemic effect. Thus, it is found out that this compound is appropriately usable as an agent for treating or preventing hyperuricemia, gout, inflammatory bowel disease, diabetic nephropathy, diabetic retinopathy and so on.