methyl 2-{3-cyano-4-[1-(triisopropylsilyl)-1H-pyrrol-3-yl]phenyl}isonicotinate

Base Information

Chemical Name:methyl 2-{3-cyano-4-[1-(triisopropylsilyl)-1H-pyrrol-3-yl]phenyl}isonicotinate
CAS No.:934470-34-5
Molecular Formula:C₂₇H₃₃N₃O₂Si
Molecular Weight:459.663
Hs Code.:

Synonyms:methyl 2-{3-cyano-4-[1-(triisopropylsilyl)-1H-pyrrol-3-yl]phenyl}isonicotinate

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Chemical Property of methyl 2-{3-cyano-4-[1-(triisopropylsilyl)-1H-pyrrol-3-yl]phenyl}isonicotinate

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Technology Process of methyl 2-{3-cyano-4-[1-(triisopropylsilyl)-1H-pyrrol-3-yl]phenyl}isonicotinate

There total 6 articles about methyl 2-{3-cyano-4-[1-(triisopropylsilyl)-1H-pyrrol-3-yl]phenyl}isonicotinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 876918-46-6
2-(3-cyano-4-{[(trifluoromethyl)sulfonyl]oxy}phenyl)isonicotinic acid methyl ester

: 138900-55-7
1-(triisopropylsilyl)-1H-pyrrole-3-boronic acid

: 934470-34-5
methyl 2-{3-cyano-4-[1-(triisopropylsilyl)-1H-pyrrol-3-yl]phenyl}isonicotinate

Guidance literature:: With potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In water; toluene;

Reference yield:

: 835898-37-8
1-(benzyloxy)-4-bromo-2-cyanobenzene

: 934470-34-5
methyl 2-{3-cyano-4-[1-(triisopropylsilyl)-1H-pyrrol-3-yl]phenyl}isonicotinate

Guidance literature:: Multi-step reaction with 5 steps

1: n-butyllithium; Triisopropyl borate / tetrahydrofuran; hexane; toluene / -78 - 20 °C

2: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; toluene / 100 °C

3: trifluoroacetic acid / pentamethylbenzene, / Heating / reflux

4: N-ethyl-N,N-diisopropylamine / dichloromethane / 0 °C

5: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene / 1 h / 130 °C / Microwave irradiation

With n-butyllithium; Triisopropyl borate; sodium carbonate; potassium carbonate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; hexane; dichloromethane; pentamethylbenzene,; water; toluene;

Reference yield:

: (3-cyano-4-benzyloxyphenyl)boronic acid

: 934470-34-5
methyl 2-{3-cyano-4-[1-(triisopropylsilyl)-1H-pyrrol-3-yl]phenyl}isonicotinate

Guidance literature:: Multi-step reaction with 4 steps

1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; toluene / 100 °C

2: trifluoroacetic acid / pentamethylbenzene, / Heating / reflux

3: N-ethyl-N,N-diisopropylamine / dichloromethane / 0 °C

4: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene / 1 h / 130 °C / Microwave irradiation

With sodium carbonate; potassium carbonate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In dichloromethane; pentamethylbenzene,; water; toluene;