934470-83-4Relevant academic research and scientific papers
Design and synthesis of long-acting inhibitors of dipeptidyl peptidase IV
Kondo, Takashi,Sugimoto, Isamu,Nekado, Takahiro,Ochi, Kenya,Ohtani, Tazumi,Tajima, Yohei,Yamamoto, Susumu,Kawabata, Kazuhito,Nakai, Hisao,Toda, Masaaki
, p. 2715 - 2735 (2008/02/08)
A series of (4-substituted prolyl)prolinenitriles were synthesized and evaluated as inhibitors of dipeptidylpeptidase IV (DPP-IV). Among those tested, the 4β-[4-(hydroxyphenyl)prolyl]prolinenitriles showed a potent inhibitory activity with a long duration
