934472-10-3

Upstream product

• 1130814-69-5 2-(1-t-butyldimethylsilyloxyethyl)-1-(4-methylphenylsulfonyl)-1,2,3,6-tetrahydropyridine 
• 95331-51-4 N-[(4-methylphenyl)sulfonyl]-L-aspartic acid 1,4-dimethyl ester 
• 934472-08-9 N-{1-[2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-pent-4-enyl}-4-methyl-benzenesulfonamide 
• 934472-07-8 2-[2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-1-(toluene-4-sulfonyl)-aziridine 
• 147136-78-5 N-(3-hydroxy-1-hydroxymethyl-propyl)-4-methylbenzenesulfonamide 
• 934472-06-7 2-hydroxyethyl-1-(toluene-4-sulfonyl)aziridine 
• 934472-09-0 N-{1-[2-(tert-butyl-dimethyl-silanyloxy)-ethyl]-5-hydroxy-pentyl}-4-methyl-benzenesulfonamide 

Downstream Products

• 934472-52-3 4-nitro-benzoic acid 1-[1-(toluene-4-sulfonyl)-piperidin-2-ylmethyl]-hexyl ester 
• 934472-49-8 4-nitro-benzoic acid 1-[1-(toluene-4-sulfonyl)-piperidin-2-ylmethyl]-hexyl ester 
• 190383-62-1 [2R-(2R)]-1-benzyloxycarbonyl-2-(2-hydroxy-4-pentenyl)piperidine 
• 26171-47-1 1-piperidin-2-yl-propan-2-ol 
• 67008-24-6 (2R)-2-((2S)-2-hydroxy-2-phenylethyl)-N-methylpiperidine 
• 67008-23-5 (2R)-2-((2R)-2-hydroxy-2-phenylethyl)-1-methylpiperidine 
• 111612-22-7 (1R)-1-Phenyl-2<(2R)-2-piperidyl>ethanol 
• 112653-26-6 (1S)-1-Phenyl-2<(2R)-2-piperidyl>ethanol 
• 251995-39-8 [2R-(2S)]-1-benzyloxycarbonyl-2-(2-hydroxypropyl)piperidine 
• 251995-42-3 [2R-(2S)]-phenylmethyl 2-(2-hydroxypent-4-enyl)piperidinecarboxylate 
• 251995-69-4 [2R-(2R)]-phenylmethyl 2-(2-hydroxyheptyl)piperidinecarboxylate 
• 251995-52-5 [2R-(2S)]-phenylmethyl 2-(2-hydroxyheptyl)piperidinecarboxylate 
• 934472-18-1 4-nitro-benzoic acid 1-phenyl-2-[1-(toluene-4-sulfonyl)-piperidin-2-yl]-ethyl ester 
• 934472-17-0 4-nitro-benzoic acid 1-phenyl-2-[1-(toluene-4-sulfonyl)-piperidin-2-yl]-ethyl ester 

Relevant academic research and scientific papers

Synthesis of N-tosylhomosphinganine and N-tosylsedridine

A straightforward synthesis of N-tosylhomosphinganine and N-tosylsedridine has been achieved from trans-4-hydroxyproline by Grignard addition, regioselective Baeyer-Villiger reaction, cross or ring-closing metathesis and hydrogenation as the key steps.

An efficient approach to 2-substituted N-tosylpiperdines: asymmetric synthesis of 2-(2-hydroxy substituted)piperidine alkaloids

We have developed an efficient and a general approach to chiral 2-substituted N-tosylpiperidines starting from chiral α-substituted-N-tosylaziridines. Using this approach, we have synthesized (+)-coniine. The synthesis of chiral N-tosyl-2-piperidinylethanol 15 and ent-15, was achieved from l- and d-aspartic acids, respectively in few steps. Piperidine 15 was converted into 2-(2-hydroxysubstituted)piperidines of type 2 in optically active form. By applying this strategy, asymmetric syntheses of halosaline (R,R)-2a, (+)- and (-)-sedamine 2b, (+)- and (-)-allosedamine 2c, (+)- and (-)-sedridine 2d, (+)- and (-)-allosedridine 2e, (+)-tetraponerine T-3 3a, T-4 3c, T-7 3b, and T-8 3d have been achieved in high yields. These stereoisomers can be interconverted via Mitsunobu inversion in excellent yields.