934477-14-2

Basic information

• Product Name: 4-bromo-6-tert-butylsalicyl alcohol
• Synonyms: 4-bromo-6-tert-butylsalicyl alcohol
• CAS NO: 934477-14-2
• Molecular Weight: 259.143
• Mol File: 934477-14-2.mol

Chemical Properties

• CAS DataBase Reference: 4-bromo-6-tert-butylsalicyl alcohol(CAS DataBase Reference)
• NIST Chemistry Reference: 4-bromo-6-tert-butylsalicyl alcohol(934477-14-2)
• EPA Substance Registry System: 4-bromo-6-tert-butylsalicyl alcohol(934477-14-2)

Safety Data

• Hazardous Substances Data: 934477-14-2(Hazardous Substances Data)

Upstream product

• 153759-58-1 5-bromo-3-tert-butyl-2-hydroxybenzaldehyde 

Downstream Products

• 1617519-29-5 C₃₀H₄₂Br₂N₂O₂ 
• 1617519-26-2 4-bromo-2-(bromomethyl)-6-(tert-butyl)phenol 
• 934477-26-6 C₁₂H₁₆O₃ 

Relevant articles and documents

Enzymatically activated cycloSal-d4T-monophosphates: The third generation of cycloSal-pronucleotides

The third generation of cycloSal-pronucleotides, 5-diacetoxymethyl- cycloSal-d4T-monophosphates (5-di-AM-cycloSal-d4TMPs), is reported as a new class of "lock-in"-modified cycloSal-pronucleotides. These compounds bear an esterase-cleavable geminal dicarboxylate (acylal) attached to the aromatic ring of the saligenyl unit. The conversion into a strong acceptor group (aldehyde) leads to a strong decrease in hydrolytic stability. As a consequence, a fast release of a nucleoside monophosphate (i.e., d4TMP) follows. The concept of this enzymatic activation is proven by hydrolysis studies in phosphate buffer, cell extracts, and human serum. These investigations showed the conversion of the acylal group into a polar aldehyde by enzymatic cleavage. Besides, antiviral activities against HIV are presented.

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