934477-26-6

Basic information

• Product Name: C₁₂H₁₆O₃
• Synonyms: C₁₂H₁₆O₃
• CAS NO: 934477-26-6
• Molecular Weight: 208.257
• Mol File: 934477-26-6.mol

Chemical Properties

• CAS DataBase Reference: C₁₂H₁₆O₃(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₂H₁₆O₃(934477-26-6)
• EPA Substance Registry System: C₁₂H₁₆O₃(934477-26-6)

Safety Data

• Hazardous Substances Data: 934477-26-6(Hazardous Substances Data)

Upstream product

• 934477-18-6 C₁₅H₂₀O₃ 
• 153759-58-1 5-bromo-3-tert-butyl-2-hydroxybenzaldehyde 
• 24623-65-2 3-tert-butyl-2-hydroxybenzaldehyde 
• 88-18-6 2-tert-Butylphenol 
• 934477-16-4 5-bromo-6-tert-butylsalicyl alcohol isopropylideneacetal 
• 934477-14-2 4-bromo-6-tert-butylsalicyl alcohol 

Relevant articles and documents

Enzymatically activated cycloSal-d4T-monophosphates: The third generation of cycloSal-pronucleotides

The third generation of cycloSal-pronucleotides, 5-diacetoxymethyl- cycloSal-d4T-monophosphates (5-di-AM-cycloSal-d4TMPs), is reported as a new class of "lock-in"-modified cycloSal-pronucleotides. These compounds bear an esterase-cleavable geminal dicarboxylate (acylal) attached to the aromatic ring of the saligenyl unit. The conversion into a strong acceptor group (aldehyde) leads to a strong decrease in hydrolytic stability. As a consequence, a fast release of a nucleoside monophosphate (i.e., d4TMP) follows. The concept of this enzymatic activation is proven by hydrolysis studies in phosphate buffer, cell extracts, and human serum. These investigations showed the conversion of the acylal group into a polar aldehyde by enzymatic cleavage. Besides, antiviral activities against HIV are presented.