934497-20-8Relevant articles and documents
Amidate Prodrugs of Deoxythreosyl Nucleoside Phosphonates as Dual Inhibitors of HIV and HBV Replication
Liu, Chao,Dumbre, Shrinivas G.,Pannecouque, Christophe,Huang, Chunsheng,Ptak, Roger G.,Murray, Michael G.,De Jonghe, Steven,Herdewijn, Piet
, p. 9513 - 9531 (2016)
The synthesis of four l-2′-deoxy-threose nucleoside phosphonates with the natural nucleobases adenine, thymine, cytosine, and guanosine has been performed. Especially the adenine containing analogue (PMDTA) was endowed with potent antiviral activity displ
NOVEL ANTIVIRAL COMPOUNDS, A PROCESS FOR THEIR PREPARATION, AND THEIR USE FOR TREATING VIRAL INFECTIONS
-
Page/Page column 8; 9; 23, (2017/01/05)
The present invention relates to novel pro-drugs of L-2'-deoxythreose nucleoside phosphonates, such as phosphoramidate, phosphorodiamidate and phospho-diester prodrugs. The invention also relates to a process for preparing these novel prodrugs of nucleoside phosphonates. The invention also relates to the use of these novel phosphonatemodified nucleosides to treat or prevent viral infections and their use to manufacture a medicine to treat or prevent viral infections, particularly infections with viruses belonging to the HBV family.
Synthesis of 3′-O-phosphonomethyl nucleosides with an adenine base moiety
Vi?a, Dolores,Wu, Tongfei,Renders, Marleen,Laflamme, Geneviève,Herdewijn, Piet
, p. 2634 - 2646 (2007/10/03)
A synthetic scheme has been developed for the synthesis of 2′-deoxythreose phosphonate nucleosides from β-hydroxy-γ-butyrolactone and of 2′-azido erythrose phosphonate nucleosides from dihydroxydihydrofuran-1-one. In addition several α-l-arabinofuranose p