934536-94-4

Upstream product

• 89938-62-5 2-chloro-5-(methylsulfonyl)benzoic acid 

Downstream Products

• 304463-93-2 [2-(3,4-dihydro-isoquinolin-1-yl)-4-methanesulfonyl-phenyl]-methyl-amine 
• 304463-92-1 1-(2-chloro-5-methanesulfonyl-phenyl)-3,4-dihydro-isoquinoline 
• 304463-90-9 2-chloro-5-methanesulfonyl-N-phenethyl-benzamide 

Relevant academic research and scientific papers

Synthesis of racemic 1,2,3,4-tetrahydroisoquinolines and their resolution

1-Aniline-substituted 3,4-dihydroisoquinolines were obtained in various ways using the Bischler-Napieralski reaction. The effect of the protecting group at the aniline nitrogen atom on the course of the reaction has been studied and it was found that the N-phthalyl group was stable under the cyclization conditions. The dihydroisoquinolines were reduced to the racemic 1,2,3,4-tetrahydroisoquinolines which were resolved by crystallization of the diastereomeric tartrates. Two examples of 1,2,3, 4-tetrahydroisoquinolines were obtained in optically pure form (>99% ee).

BENZOXAZOLES USEFUL IN THE TREATMENT OF INFLAMMATION

There is provided the use of a compound of formula (I),wherein Y, W1 to W4, Z1 to Z4 and R have meanings given in the description, and pharmaceutically-acceptable salts thereof, for the manufacture of a medicame