934562-63-7

Upstream product

• 89-75-8 2,4-dichlorobenzoyl chloride 
• 74390-79-7 (2,6-dichloro-4-hydroxyphenyl)(2,4-dichlorophenyl)methanone 
• 934562-64-8 (2,6-dichloro-4-methoxyphenyl)(2,4-dichlorophenyl)methanone 
• 33719-74-3 3,5-dichloroanisole 
• 934562-72-8 ethyl 7-(3,5-dichloro-4-(2,4-dichlorobenzoyl)phenoxy)heptanoate 

Relevant academic research and scientific papers

Acid and base stable diphenylmethanol derivatives and methods of use

The invention provides compounds that are useful as linkers for solid phase synthesis and as protecting groups, and methods for producing and using the same.

Polymer-supported (2,6-dichloro-4-alkoxyphenyl)(2,4-dichlorophenyl) methanol: A new linker for solid-phase organic synthesis

(Chemical Equation Presented) An acid and base stable hydroxytetrachlorodiphenylmethyl (HTPM) linker is developed for polymer-supported organic synthesis. The linkers reported here are utilized for loading carboxylic acids, amines, alcohols, and phenols, and are stable to Bronsted and Lewis acids, Bronsted bases, and a wide variety of nucleophiles. However, the HTPM linkers can conveniently be cleaved by the solvolytic displacement reactions with 20% TFA.