Cas 934568-25-9,1H-Pyrrolo[2,3-b]pyridine, 6-chloro-1-Methyl-

934568-25-9

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Basic information

Product Name: 1H-Pyrrolo[2,3-b]pyridine, 6-chloro-1-Methyl-
Synonyms: 1H-Pyrrolo[2,3-b]pyridine, 6-chloro-1-Methyl-;6-chloro-1-methyl-1H-pyrrolo[2,3-b]pyridine
CAS NO:934568-25-9
Molecular Formula: C8H7ClN2
Molecular Weight: 166.60758
EINECS: N/A
Product Categories: N/A
Mol File: 934568-25-9.mol

Chemical Properties

Melting Point: N/A
Boiling Point: N/A
Flash Point: N/A
Appearance: /
Density: N/A
Refractive Index: N/A
Storage Temp.: N/A
Solubility: N/A
CAS DataBase Reference: 1H-Pyrrolo[2,3-b]pyridine, 6-chloro-1-Methyl-(CAS DataBase Reference)
NIST Chemistry Reference: 1H-Pyrrolo[2,3-b]pyridine, 6-chloro-1-Methyl-(934568-25-9)
EPA Substance Registry System: 1H-Pyrrolo[2,3-b]pyridine, 6-chloro-1-Methyl-(934568-25-9)

Safety Data

Hazard Codes: N/A
Statements: N/A
Safety Statements: N/A
WGK Germany:
RTECS:
HazardClass: N/A
PackingGroup: N/A
Hazardous Substances Data: 934568-25-9(Hazardous Substances Data)

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934568-25-9 Usage

Structure

Pyridine ring fused to a pyrrole ring

Unique features

Chlorine atom at the 6th position on the pyridine ring, methyl group at the 1st position

Uses

Potential applications in organic synthesis and pharmaceutical research

Safety

Handle with care and follow safety guidelines due to potential hazards.

Check Digit Verification of cas no

The CAS Registry Mumber 934568-25-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 9,3,4,5,6 and 8 respectively; the second part has 2 digits, 2 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 934568-25:
(8*9)+(7*3)+(6*4)+(5*5)+(4*6)+(3*8)+(2*2)+(1*5)=199
199 % 10 = 9
So 934568-25-9 is a valid CAS Registry Number.

934568-25-9Upstream product

934568-25-9Downstream Products

934568-25-9Relevant academic research and scientific papers

SUBSTITUTED QUINOXALINE DERIVATIVES

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Page/Page column 195, (2016/12/01)

The present invention relates to substituted quinoxaline derivatives. These compounds are useful for the prevention and/or treatment of several medical conditions including hyperproliferative disorders and diseases.

SUBSTITUTED QUINOXALINE DERIVATIVES

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Page/Page column 121; 122, (2016/11/28)

Discovery of N-[5-(6-Chloro-3-cyano-1-methyl-1H-indol-2-yl)-pyridin-3-ylmethyl]-ethanesulfonamide, a Cortisol-Sparing CYP11B2 Inhibitor that Lowers Aldosterone in Human Subjects

Papillon, Julien P. N.,Lou, Changgang,Singh, Alok K.,Adams, Christopher M.,Ksander, Gary M.,Beil, Michael E.,Chen, Wei,Leung-Chu, Jennifer,Fu, Fumin,Gan, Lu,Hu, Chii-Whei,Jeng, Arco Y.,Lasala, Daniel,Liang, Guiqing,Rigel, Dean F.,Russell, Kerry S.,Vest, John A.,Watson, Catherine

, p. 9382 - 9394 (2015/12/23)

Human clinical studies conducted with LCI699 established aldosterone synthase (CYP11B2) inhibition as a promising novel mechanism to lower arterial blood pressure. However, LCI699's low CYP11B1/CYP11B2 selectivity resulted in blunting of adrenocorticotropic hormone-stimulated cortisol secretion. This property of LCI699 prompted its development in Cushing's disease, but limited more extensive clinical studies in hypertensive populations, and provided an impetus for the search for cortisol-sparing CYP11B2 inhibitors. This paper summarizes the discovery, pharmacokinetics, and pharmacodynamic data in preclinical species and human subjects of the selective CYP11B2 inhibitor 8.

ARYL PYRIDINE AS ALDOSTERONE SYNTHASE INHIBITORS

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Page/Page column 101-102, (2012/04/23)

The present invention provides a compound of Formula (I); a method for manufacturing the compounds of the invention, and its therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.

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