934593-36-9Relevant articles and documents
Development of a large scale asymmetric synthesis of vanilloid receptor (TRPV1) antagonist ABT-102
Lukin, Kirill,Hsu, Margaret C.,Chambournier, Gilles,Kotecki, Brian,Venkatramani,Leanna
, p. 578 - 584 (2012/12/31)
A highly efficient asymmetric synthesis of TRPV1 antagonist ABT-102 was developed and successfully demonstrated on a multi-kilogram scale. This process incorporates a new asymmetric synthesis of (R)-tert-butylaminoindan, which is based on a chiral auxiliary induced diastereoselective reduction of its iminoindan precursor.