4600-86-6

Basic information

• Product Name: 5-TERT-BUTYL-2,3-DIHYDROINDEN-1-ONE
• Synonyms: 5-TERT-BUTY1-2,3-DIHYDROINDEN-1-ONE;5-tert-Butylindan-1-one;5-(tert-Butyl)-2,3-dihydro-1H-inden-1-one;5-TERT-BUTYL-2,3-DIHYDROINDEN-1-ONE
• CAS NO: 4600-86-6
• Molecular Formula: C₁₃H₁₆O
• Molecular Weight: 188.26554
• Mol File: 4600-86-6.mol
• Article Data: 15

Chemical Properties

• Boiling Point: 280.721°C at 760 mmHg
• Flash Point: 114.88°C
• Appearance: /
• Density: 1.036g/cm³
• Vapor Pressure: 0.004mmHg at 25°C
• Refractive Index: 1.539
• CAS DataBase Reference: 5-TERT-BUTYL-2,3-DIHYDROINDEN-1-ONE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-TERT-BUTYL-2,3-DIHYDROINDEN-1-ONE(4600-86-6)
• EPA Substance Registry System: 5-TERT-BUTYL-2,3-DIHYDROINDEN-1-ONE(4600-86-6)

Safety Data

• Hazardous Substances Data: 4600-86-6(Hazardous Substances Data)

Usage

General Description

5-tert-Butyl-2,3-dihydroinden-1-one is a chemical compound with the molecular formula C13H18O. It is a white solid that is used in the production of fragrances and flavors due to its pleasant odor. It is also used as a key intermediate in the synthesis of pharmaceuticals and other organic compounds. 5-tert-Butyl-2,3-dihydroinden-1-one is known for its high purity and stability, making it a valuable component in various industries. Its structure consists of a tert-butyl group attached to a dihydroindenone moiety, giving it its unique properties and applications.

InChI:InChI=1/C13H16O/c1-13(2,3)10-5-6-11-9(8-10)4-7-12(11)14/h5-6,8H,4,7H2,1-3H3

Upstream product

• 253185-03-4 tert-butylbenzene 
• 625-36-5 2-chloropropionyl chloride 
• 53987-61-4 3-(3'-t-Butylphenyl)-propionsaeure 
• 28547-33-3 1-(4-(tert-butyl)phenyl)-3-chloropropan-1-one 

Downstream Products

• 1178884-68-8 6-(tert-butyl)-3,4-dihydroisoquinolin-1(2H)-one 
• 1198764-90-7 C₁₃H₁₇NO 
• 808756-83-4 (1R)-5-tert-butyl-2,3-dihydro-1H-inden-1-ylamine 
• 935680-90-3 5-tert-butyl-2,3-dihydro-1H-inden-1-ylamine 
• 4600-87-7 5-tert.-Butyl-2-(4-dimethylamino-benzyliden)-indanon-⁽¹⁾ 
• 808756-71-0 N-[(1R)-5-tert-butyl-2,3-dihydro-1H-inden-1-yl]-N'-1H-indazol-4-ylurea 
• 934593-36-9 (1R)-5-tert-butyl-indan-1-ylamine tosylate 

Relevant articles and documents

PYRAZOLO[3,4-b]PYRIDINE AND PYRROLO[2,3-b]PYRIDINE INHIBITORS OF BRUTON'S TYROSINE KINASE

Disclosed are pyrazolo[3,4-b]pyridine and pyrrolo[2,3-b]pyridine inhibitors of Bruton's tyrosine kinase (Btk). Also disclosed are pharmaceutical compositions that include the compounds. Methods of using the Btk inhibitors are described, alone or in combin

Preparation, physical properties and n-type FET characteristics of substituted diindenopyrazinediones and bis(dicyanomethylene) derivatives

A series of halogen and alkyl substituted diindenopyrazinediones and bis(dicyanomethylene) derivatives have been synthesized as new n-type organic semiconductors based on nitrogen-containing heterocycles. Halogen groups were introduced to improve the electron injection. Their crystal structures and solid physical properties are discussed. Alkyl groups were introduced to increase the solubility in organic solvents. Furthermore, hexanoyl groups were introduced by oxidation of alkyl groups to increase the solubility and electron affinity. Dicyanomethylene groups were also introduced to further enhance the electron-accepting properties. Drop-cast as well as vapour deposited thin films showed n-type FET properties.

INHIBITORS OF BURTON'S TYROSINE KINASE

This application discloses 5-phenyl-1H-pyrazin-2-one derivatives according to generic Formulae I-V: wherein, variables Q, R, Y1, Y2, Y2′, Y3, Y4, n and m are defined as described herein, which inhibit Btk. The compounds disclosed herein are useful to modulate the activity of Btk and treat diseases associated with excessive Btk activity. The compounds are further useful to treat inflammatory and auto immune diseases associated with aberrant B-cell proliferation such as rheumatoid arthritis. Also disclosed are compositions comprising compounds of Formulae I-V and at least one carrier, diluent or excipient.