934593-90-5

Basic information

• Product Name: OTAVA-BB 7070707015
• Synonyms: OTAVA-BB 7070707015;CAY10585;HIF-1α inhibitor;LW6;LW8;4-Hydroxy-3-[[2-(4-tricyclo[3.3.1.13,7]dec-1-ylphenoxy)acetyl]aMino]-benzoic Acid Methyl Ester;Hypoxia inducible factor-1α inhibitor;LW 6 (This product is unavailable in the U.S.)
• CAS NO: 934593-90-5
• Molecular Formula: C₂₆H₂₉NO₅
• Molecular Weight: 435.51216
• Product Categories: Aromatics, Inhibitors
• Mol File: 934593-90-5.mol
• Article Data: 10

Chemical Properties

• Boiling Point: 647.4±55.0 °C(Predicted)
• Appearance: /
• Density: 1.295±0.06 g/cm3(Predicted)
• PKA: 7.59±0.48(Predicted)
• CAS DataBase Reference: OTAVA-BB 7070707015(CAS DataBase Reference)
• NIST Chemistry Reference: OTAVA-BB 7070707015(934593-90-5)
• EPA Substance Registry System: OTAVA-BB 7070707015(934593-90-5)

Safety Data

• Hazardous Substances Data: 934593-90-5(Hazardous Substances Data)

Usage

Description

OTAVA-BB 7070707015 is a product that contains Glycerol, a colorless, odorless, and viscous liquid with a sweet taste. Glycerol is a versatile compound with a wide range of applications across various industries due to its unique properties, such as its ability to absorb moisture, act as a humectant, and serve as a solvent.

Uses

Used in Pharmaceutical Industry:
OTAVA-BB 7070707015 is used as a pharmaceutical excipient for its ability to increase the solubility of drugs, improve the stability of formulations, and act as a plasticizer.
Used in Cosmetics Industry:
OTAVA-BB 7070707015 is used as a humectant in cosmetics to help retain moisture in the skin, providing hydration and improving the texture of the product.
Used in Food Industry:
OTAVA-BB 7070707015 is used as a sweetener, emulsifier, and preservative in various food products to enhance taste, texture, and shelf life.
Used in Personal Care Industry:
OTAVA-BB 7070707015 is used in personal care products such as toothpaste, mouthwashes, and shaving creams to provide lubrication, improve texture, and maintain moisture.
Used in Industrial Applications:
OTAVA-BB 7070707015 is used as a solvent in various industrial processes, including the manufacturing of resins, inks, and dyes.
Used in Biodiesel Production:
OTAVA-BB 7070707015 is used as a co-solvent in the production of biodiesel to improve the efficiency of the process and reduce the viscosity of the final product.
Used in Agriculture:
OTAVA-BB 7070707015 is used in agriculture as a humectant and fertilizer additive to improve the absorption of nutrients by plants and enhance crop yields.

Upstream product

• 99-42-3 methyl (4-hydroxy-3-nitro)benzoate 
• 616-82-0 3-nitro-4-hydroxybenzoic acid 
• 1205117-27-6 C₁₈H₂₁ClO₂ 
• 536-25-4 methyl 3-amino-4-hydroxybenzoate 
• 52804-26-9 (4-adamantan-1-yl-phenoxy)acetic acid 
• 29799-07-3 4-adamantylphenol 
• 52804-25-8 (4-adamantyl-1-yl-phenoxy) acetic acid ethyl ester 

Downstream Products

• 934593-92-7 AC₁-001 
• 1469268-26-5 methyl 3-[2-(4-adamantan-1-yl-phenoxy)acetylamino]-4-(2,2-dimethyl-4,15-dioxo-3,8,11-trioxa-5,14-diazahexadecan-16-yloxy)benzoate 

Relevant articles and documents

NOVEL COMPOUND HAVING MALATE DEHYDROGENASE INHIBITORY ACTIVITY AND PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING CANCER COMPRISING SAME AS ACTIVE INGREDIENT

The present invention relates to a compound exhibiting inhibitory activity of at least one of malate dehydrogenases I (MDH1) and malate dehydrogenases 2 (MDH2), and a pharmaceutical composition for preventing or treating cancer comprising the same as an active ingredient. The inventors of the present invention have experimentally confirmed that the compound exhibiting the MDH1 and/or MDH2 inhibitory activity has an inhibitory effect on mitochondrial respiration in cancer cells, an excellent inhibitory effect on cancer cell growth, etc. Thus, the compound of the present invention is expected to be effectively used as a pharmaceutical composition for treating cancer.

Synthesis and structure-activity relationship study of chemical probes as hypoxia induced factor-1α/malate dehydrogenase 2 inhibitors

A structure-activity relationship study of hypoxia inducible factor-1α inhibitor 3-aminobenzoic acid-based chemical probes, which were previously identified to bind to mitochondrial malate dehydrogenase 2, was performed to provide a better understanding of the pharmacological effects of LW6 and its relation to hypoxia inducible factor-1α (HIF-1α) and malate dehydrogenase 2 (MDH2). A variety of multifunctional probes including the benzophenone or the trifluoromethyl diazirine for photoaffinity labeling and click reaction were prepared and evaluated for their biological activity using a cell-based HRE-luciferase assay as well as a MDH2 assay in human colorectal cancer HCT116 cells. Among them, the diazirine probe 4a showed strong inhibitory activity against both HIF-1α and MDH2. Significantly, the inhibitory effect of the probes on HIF-1α activity was consistent with that of the MDH2 enzyme assay, which was further confirmed by the effect on in vitro binding activity to recombinant human MDH2, oxygen consumption, ATP production, and AMP activated protein kinase (AMPK) activation. Competitive binding modes of LW6 and probe 4a to MDH2 were also demonstrated.

ARYLOXY PHENOXY ACRYLIC COMPOUND HAVING HIF-1 INHIBITION ACTIVITY, METHOD FOR PREPARING SAME, AND PHARMACEUTICAL COMPOSITION CONTAINING SAME AS AN ACTIVE INGREDIENT

The present invention relates to a compound inhibiting HF-1 activity, a preparation method of the same, and a pharmaceutical composition comprising the same as an active ingredient. The compound of the present invention demonstrates anticancer activity no