934601-50-0Relevant academic research and scientific papers
Simple, stable, and versatile double-allylation reagents for the stereoselective preparation of skeletally diverse compounds
Peng, Feng,Hall, Dennis G.
, p. 3070 - 3071 (2007)
A new and efficient class of double-allylation reagents, α-trimethylsilylmethyl allylboronate 1 and the crotylboronates 12, is reported. These stable bimetallicreagents are prepared easily in enantiomerically pure form and add under BF3 catalysis onto a wide range of aldehydes to afford a direct access to hydroxyl-functionalized allylic silanes in very high E/Z selectivity and excellent enantioselectivity (up to 98% ee). The useful hydroxyl-functionalized allylsilane intermediates can be exploited in chemodivergent syntheses of various compound classes such as acyclic propionate units, polysubstituted furans, vinylcyclopropanes, and larger carbocycles. Copyright
