93472-18-5

Basic information

• Product Name: 3(2H)-Thiazolecarboxylic acid, 2-(2-oxo-2-phenylethyl)-, ethyl ester
• CAS NO: 93472-18-5
• Molecular Formula: C14H15NO3S
• Molecular Weight: 277.344
• Mol File: 93472-18-5.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 3(2H)-Thiazolecarboxylic acid, 2-(2-oxo-2-phenylethyl)-, ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 3(2H)-Thiazolecarboxylic acid, 2-(2-oxo-2-phenylethyl)-, ethyl ester(93472-18-5)
• EPA Substance Registry System: 3(2H)-Thiazolecarboxylic acid, 2-(2-oxo-2-phenylethyl)-, ethyl ester(93472-18-5)

Safety Data

• Hazardous Substances Data: 93472-18-5(Hazardous Substances Data)

Upstream product

• 288-47-1 1,3-thiazole 
• 13735-81-4 1-styrenyloxytrimethylsilane 
• 541-41-3 chloroformic acid ethyl ester 
• 93472-12-9 N-Ethoxycarbonyl-1,3-thiazolium chloride 
• 98-86-2 acetophenone 

Relevant articles and documents

Addition of silyl enol ethers to imidazoles and thiazoles in the presence of alkyl chloroformate

Various kinds of silyl enol ethers and ketene silyl acetals react with imidazole, thiazole and their benzo-derivatives in the presence of an alkyl chloroformate to give 2-substituted imidazolines and thiazolines in good yields.

One pot reaction of unstable N-acyl quaternary salt of thiazoles or imidazoles with silyl enol ethers formed in situ

Ketone, trimethylsilyl triflate, triethylamine, thiazole or imidazole, and alkyl chloroformate were sequentially added to methylene chloride to form 2-substituted N-alkoxycarbonylated thiazoline or imidazoline derivatives in good yields.

REGIOSELECTIVE CARBON-CARBON BOND FORMATION AT C2 OF 1,3-THIAZOLE BY REACTION OF N-ETHOXYCARBONYLTHIAZOLIUM CHLORIDE WITH C-NUCLEOPHILES

N-Ethoxycarbonylthiazolium chloride generated in situ from 1,3-thiazole and ethyl chloroformate, treated with lithium carbanions of esters, Grignard reagents, silyl enol ethers and esters, undergo nucleophilic addition at C2 affording the corresponding 2-substituted N-ethoxycarbonylthiazolines.