93474-55-6Relevant academic research and scientific papers
New carboxamides bearing benzenesulphonamides: Synthesis, molecular docking and pharmacological properties
Eze, Florence Uchenna,Okoro, Uchechukwu Chris,Ugwu, David Izuchukwu,Okafor, Sunday N.
, (2019/09/18)
Ten new derivatives of benzenesulphonamide bearing carboxamide functionality were synthesized and investigated for their in vitro antimicrobial, antioxidant and in vivo anti-inflammatory activities. Compound 9d inhibited carrageenan induced rat-paw oedema
Design, synthesis and in vitro biochemical activity of novel amino acid sulfonohydrazide inhibitors of MurC
Frlan, Rok,Kovas, Andreja,Blanot, Didier,Gobec, Stanislav,Pecar, Slavko,Obreza, Ales
scheme or table, p. 295 - 310 (2012/04/23)
Mur ligases are essential enzymes involved in the cytoplasmic steps of peptidoglycan synthesis which remain attractive, yet unexploited targets. In order to develop new antibacterial agents, we have designed a series of new MurC and MurD inhibitors bearin
Synthesis and Reactivity of β-Lactones Derived from L-Threonine and Related Amino Acids
Pansare, Sunil V.,Vederas, John C.
, p. 2311 - 2316 (2007/10/02)
The synthesis and nucleophilic ring opening of optically pure N-protected α-amino-β-alkyl β-lactones was investigated.Treatment of N-BOC-L-threonine (8) and N-BOC-L-allo-threonine (9) under modified Mitsunobu conditions (Ph3P, dimethyl azodicarboxylate, -
α-Amino Acids as Chiral Educts for Asymmetric Products. Chirospecific Syntheses of Methyl L-Sibirosaminide and Its C-3 Epimer from L-Allothreonine
Maurer, Peter J.,Knudsen, Christopher G.,Palkowitz, Alan D.,Papoport, Henry
, p. 325 - 332 (2007/10/02)
Efficient syntheses of methyl L-sibirosaminide and its C-3 epimer are described using L-allothreonine as the chiral educt.Amino acylations of organometallics with the lithium salt of N-(phenylsulfonyl)-L-allothreonine constitute the key carbon-carbon bond
