934749-89-0Relevant academic research and scientific papers
Synthesis of allocolchicines using sequential ring-closing enyne metathesis - Diels - Alder reactions
Boyer, Francois-Didier,Hanna, Issam
, p. 715 - 718 (2007)
New allocolchinoids having functionality in the C ring at position C10 or C11 have been synthesized using the enyne ring-closing metathesis (RCM) reaction for construction of the seven-membered ring and a Diels-Alder-aromatization sequence for the elabora
Synthesis of new allocolchicinoids with seven- and eight-membered B-rings by enyne ring-closing metathesis
Boyer, Francois-Didier,Hanna, Issam
experimental part, p. 4938 - 4948 (2009/06/06)
Total syntheses of allocolchicines 4 and 5, with the ester functionality in the C-ring at the C10 or C11 positions, is reported. An asymmetric synthesis of (7S)-allocolchicine 5 is also described. The main features included the elaboration of a common int
