934826-68-3

Basic information

• Product Name: SKQ1 Bromide
• Synonyms: SKQ1 Bromide;(10-(4,5-Dimethyl-3,6-dioxocyclohexa-1,4-dien-1-yl)decyl)triphenylphosphonium bromide;Visomitin
• CAS NO: 934826-68-3
• Molecular Formula: C36H42BrO2P
• Molecular Weight: 617.62
• EINECS: 604-604-1
• Mol File: 934826-68-3.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• Storage Temp.: Hygroscopic, -20°C Freezer, Under inert atmosphere
• Solubility: Chloroform (Slightly), Methanol (Slightly)
• CAS DataBase Reference: SKQ1 Bromide(CAS DataBase Reference)
• NIST Chemistry Reference: SKQ1 Bromide(934826-68-3)
• EPA Substance Registry System: SKQ1 Bromide(934826-68-3)

Safety Data

• Hazardous Substances Data: 934826-68-3(Hazardous Substances Data)

Usage

Description

SKQ1 (bromide) is a mitochondria-targeted antioxidant that decreases transmembrane potential and production of reactive oxygen species (ROS). SKQ1 prevents neuronal loss and synaptic damage in a rat model of spontaneous Alzheimer’s disease, as well as decreases severity of arthritic lesions in rats. SKQ1 slows development of age-related ocular pathologies in murine, porcine, bovine, and canine model systems. It also prevents acute phenoptosis following rhabdomyolysis, stroke, and myocardial infarction.

Uses

Visomitin is a mitochondria-targeted antioxidant with the ability to delay some manifestations of aging.

Upstream product

• 526-86-3 2,3-dimethyl-1,4-benzoquinone 
• 608-43-5 2,3-dimethyl-1,4-dihydroxybenzene 
• 7530-96-3 (11-carboxyundecyl)triphenylphosphonium bromide 
• 2834-05-1 11-bromoundecanoic acid 
• 603-35-0 triphenylphosphine 
• 526-75-0 2,3-Dimethylphenol 
• 128209-65-4 2,3-dimethyl-5-(10'-bromodecyl)-1,4-benzoquinone 

Relevant articles and documents

BIOLOGICALLY ACTIVE COMPOUNDS SPECIFICALLY DELIVERED INTO MITOCHONDRIA

This invention relates to biology and medicine and, in particular, can be used in medicine to make a pharmaceutical composition for targeted delivery of biologically active substances into mitochondria, driven by proton electro-chemical potential in the mitochondria. This invention also relates to the method to affect an organism by the targeted delivery of biologically active compounds to mitochondria. The invention can be useful in treatment of diseases or disorders associated with not normal functioning of mitochondria, in particular diseases associated with increased production of free radicals and reactive oxygen species.

PHARMACEUTICAL SUBSTANCES ON THE BASIS OF MITOCHONDRIA-ADDRESSED ANTIOXIDANTS

This invention relates to the fields of pharmaceutics and medicine, and, in particular, relates to the production and use of pharmaceutical substances on the basis of mitochondria-addressed compounds. The invention discloses methods for synthesis, purification and storage of mitochondria-addressed antioxidants, making it possible to produce said substances in a form and quality meeting the demands made on active ingredients of medicinal preparations—the pharmaceutical substances. The invention also discloses methods for design and selection of new mitochondria-addressed antioxidants having specified properties.