934837-74-8Relevant academic research and scientific papers
The role of fluorine substitution in the structure-activity relationships (SAR) of classical cannabinoids
Crocker, Peter J.,Mahadevan, Anu,Wiley, Jenny L.,Martin, Billy R.,Razdan, Raj K.
, p. 1504 - 1507 (2007)
A facile synthesis of 1-fluoro-1-deoxy-Δ8-THC analogs with side chains seven carbons in length, in the alkane/ene/yne- series (6, 5, and 4), was achieved from 1-fluoro-3,5-dimethoxybenzene (1). In vitro studies show that substitution by a fluorine has a significant detrimental effect on CB1 binding which is supported by in vivo testing. The implications of these results on the SAR of classical cannabinoids are discussed.
