93489-13-5

Usage

Molecular weight

211.22 g/mol

Physical state

Liquid

Appearance

Colorless to pale yellow liquid

Odor

Sharp, pungent

Reactivity

Highly reactive

Uses

Building block in the synthesis of various polymers and resins, utilized in the production of adhesives, coatings, and sealants

Functionality

Isocyanate functionality allows for the formation of strong and durable bonds, essential component in the manufacture of high-performance materials

Safety precautions

Can cause skin and respiratory irritation, proper safety precautions should be taken when working with it.

Upstream product

• 75-44-5 phosgene 
• 20781-21-9 2,4-dimethoxybenzylamine hydrochloride 
• 6496-89-5 2,4-dimethoxyphenylacetic acid 
• 32315-10-9 bis(trichloromethyl) carbonate 
• 20781-20-8 2,4-Dimethoxybenzylamine 

Downstream Products

• 1010071-94-9 C₂₁H₃₆N₂O₆Si 
• 1161825-83-7 3-(2,4-dimethoxybenzyl)-4-oxo-3,4-dihydroimidazo[5,1-d][1,2,3,5]tetrazine-8-carboxamide 
• 1133981-87-9 4,6-O-di-tert-butylsilylene-3O-(N-2,4-dimethoxybenzyl)carbamoyl-D-glucal 
• 1269646-82-3 (5S)-3-(2,4-dimethoxybenzyl)-5-(propan-2-yl)imidazolidine-2,4-dione 
• 1269646-83-4 (4S)-1-(2,4-dimethoxybenzyl)-4-(propan-2-yl)imidazolidine-2-one 

Relevant academic research and scientific papers

Synthesis and growth-inhibitory activities of imidazo?5,1-d]-1,2,3,5-tetrazine-8-carboxamides related to the anti-tumour drug temozolomide, with appended silicon, benzyl and heteromethyl groups at the 3-position

A series of 3-(benzyl-substituted)-imidazo?5,1-d]-1,2,3,5-tetrazines (13) and related derivatives with 3-heteromethyl groups has been synthesised and screened for growth-inhibitory activity in vitro against two pairs of glioma cell lines with temozolomide-sensitive and -resistant phenotypes dependent on the absence/presence of the DNA repair protein O6-methylguanine-DNA methyltransferase (MGMT). In general the compounds had low inhibitory activity with GI50 values >50 μM against both sets of cell lines. Two silicon-containing derivatives, the TMS-methylimidazotetrazine (9) and the SEM-analogue (10), showed interesting differences: compound (9) had a profile very similar to that of temozolomide with the MGMT+ cell lines being 5 to 10-fold more resistant than MGMT- isogenic partners; the SEM-substituted compound (10) showed potency across all cell lines irrespective of their MGMT status.

Heterocyclic Substituted, Anellated Pyrazole Derivative and its uses

The present application relates to novel heterocyclyl-substituted fused pyrazole derivatives, to processes for their preparation, to their use, alone or in combination, for the treatment and/or prevention of diseases and to their use for preparing medicaments for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of cardiovascular disorders.

3-SUBSTITUTED-4-OXO-3,4-DIHYDRO-IMIDAZO-[5,1-D][1,2,3,5-TETRAZINE-8-CARBOXYLIC ACID AMIDES AND THEIR USE

The present invention pertains generally to the field of therapeutic compounds, and more specifically to certain 3-substituted-4-oxo-3,4-dihydro-imidazo[5,1-d][1,2,3,5]tetrazine-8-carboxylic acid amide (collectively referred to herein as 3TM compounds). The present invention also pertains to pharmaceutical compositions comprising such compounds, and the use of such compounds and compositions, both in vitro and in vivo, to inhibit cell proliferation, and in the treatment of proliferative disorders such as cancer, etc., and methods of preparing such compounds.

DYKAT of vinyl aziridines: Total synthesis of (+)-pseudodistomin D

(Chemical Equation Presented) A concise total synthesis of (+)-pseudodistomin D was developed. The absolute stereochemistry was established through a dynamic kinetic asymmetric cycloaddition of an isocyanate to a vinyl aziridine. The piperidine core was c

(-)-(3aS)-Eseroline carbamate (II), a potent cholinesterase inhibitor and close analogue of physostigmine: Reanalysis

(-)-Eseroline 8 on reaction with trimethylsilyl isocyanate in refluxing toluene directly gave the crystalline tricyclic urea 2. Carbamate 1 was made by debenzylation of 2′,4′-dimethoxybenzylcarbamate 17. The structures of carbamate 1 and tricyclic urea 2 were confirmed by X-ray crystallography. Carbamate 1, like physostigmine, was found to possess high inhibitory activity against human acetyl- (AChE) and butyrylcholinesterase (BChE) in vitro and potent action when administered to rats in in vivo studies.