93493-65-3

Upstream product

• 5350-93-6 6-Chloro-pyridin-3-ylamine 
• 3282-30-2 pivaloyl chloride 

Downstream Products

• 183741-81-3 3-(tert-butylcarbonylamino)-6-chloroisonicotinic acid 
• 93493-66-4 N-(6-Chloro-4-formyl-3-pyridinyl)-2,2-dimethylpropanamide 
• 1309365-50-1 N-(4-formyl-6-o-tolylpyridin-3-yl)pivalamide 
• 127446-44-0 N-<6-Chloro-4-(hydroxymethyl)-3-pyridinyl>-2,2-dimethylpropanamide 
• 93493-68-6 6-Chloro-1,7-naphthyridin-2-one 
• 127446-36-0 2,2-Dimethyl-N-<4-(1,1-dimethylethyl)-6-oxo-1,4,5,6-tetrahydro-3-pyridinyl>propanamide 

Relevant academic research and scientific papers

AMINO HETEROARYL COMPOUNDS AS BETA-SECRETASE MODULATORS AND METHODS OF USE

The present invention comprises a new class of compounds useful for the modulation of Beta-secretase enzyme activity and for the treatment of Beta-secretase mediated diseases, including Alzheimer?s disease (AD) and related conditions. In one embodiment, the compounds have a general Formula I wherein ring A, B1, B2, B3, L, R1, R4, R5 and m of Formula I are defined herein. The invention also includes use of these compounds in pharmaceutical compositions for treatment, prophylactic or therapeutic, of disorders and conditions related to the activity of beta-secretase protein. Such disorders include, for example, Alzheimer?s Disease (AD), cognitive deficits, cognitive impairment, schizophrenia and other central nervous system conditions related to and/or caused by the formation and/or deposition of plaque on the brain. The invention also comprises further embodiments of Formula I, intermediates and processes useful for the preparation of compounds of Formula I

Synthesis and evaluation of novel 3,4,6-substituted 2-quinolones as FMS kinase inhibitors

A series of 3,4,6-substituted 2-quinolones has been synthesized and evaluated as inhibitors of the kinase domain of macrophage colony-stimulating factor-1 receptor (FMS). The fully optimized compound, 4-(4-ethyl-phenyl)-3-(2-methyl-3H-imidazol-4-yl)-2-qui

A General Approach to the Synthesis of 1,6-, 1,7-, and 1,8-Naphthyridines

A new three-step procedure for pyridine annulation is described and illustrated with efficient syntheses of various 1,6-, 1,7-, and 1,8-naphthyridin-2-ones as well as 6-chloroquinolin-2-one.The regiospecific ortho metalation and subsequent formylation of

Naphthyridinyloxy(or thio)phenoxy propanoic acids, derivatives thereof and methods of herbicidal use

Novel 2-naphthyridinyloxy(or thio)phenoxy propanoic acid compounds of the formula STR1 wherein STR2 represents a 6 membered nitrogen containing an aromatic ring which forms a 1,5-, 1,6-, 1,7- or 1,8-naphthyridinyl moiety with the adjoining pyridine ring,