934962-78-4

Upstream product

• 10313-60-7 3,4-dimethoxyphenylacetyl chloride 
• 934962-72-8 1-aza-spiro[4.4]non-8-en-7-one 
• 157138-05-1 tert-butyl 7-oxo-1-azaspiro<4.4>non-8-ene-1-carboxylate 

Relevant academic research and scientific papers

Highly efficient formal synthesis of cephalotaxine, using the stevens rearrangement-acid lactonization sequence as a key transformation

Cephalotaxine (1), the major alkaloid isolated from Cephalotaxus species, has attracted considerable attention due to the promising antitumor activity of several of its derivatives and its unique structural features. Herein we describe a highly efficient formal synthesis of 1 employing the [2,3]-Stevens rearrangement-acid lactonization sequence as a key transformation from readily available (3,4-dimethoxyphenyl)acetic acid, methyl prolinate, and allyl bromide.

Novel formal synthesis of cephalotaxine via a facile friedel - Crafts cyclization

Figure presented A novel formal synthesis of cephalotaxine (CET), the parent structure of the antileukemia Cephalotaxus alkaloids, was achieved via a facile Friedel-Crafts cyclization of the amino (or amido) spiro-cyclopentenone precursor (A) mediated by