934965-69-2

Upstream product

• 934965-65-8 4-bromo-2-iodo-6-methylpyridin-3-yl 4-chlorobenznesulfonate 
• 51934-41-9 4-iodobenzoic acid ethyl ester 
• 934965-62-5 2,4-diiodo-3-hydroxy-6-methylpyridine 
• 934965-61-4 2,4-diiodo-6-methylpyridin-3-yl 4-chlorobenzenesulfonate 
• 1121-78-4 5-Hydroxy-2-methylpyridine 
• 23003-30-7 2-iodo-6-methyl-3-pyridinol 

Relevant academic research and scientific papers

Preparation of functionalized 3,4-pyridynes via 2-magnesiated diaryl sulfonates

The preparation of functionalized 3,4-pyridynes of type 1 as highly reactive intermediates has been achieved by the controlled elimination of readily generated 2-magnesiated diaryl sulfonates of type 2 obtained by a low temperature I/Mg- or Br/Mg-exchange starting from the corresponding halides of type 3. After trapping with furan, moderate to good yields of the desired functionalized cycloadducts of type 4 are obtained. The addition of a magnesium arylthiolate or magnesium phenylselenide to 3,4-pyridyne followed by quenching with an electrophile is also described.