934971-02-5

Basic information

• Product Name: (2R,3S)-1-chloro-3-amino-4-phenyl-2-butanol sulfuric acid salt
• Synonyms: (2R,3S)-1-chloro-3-amino-4-phenyl-2-butanol sulfuric acid salt
• CAS NO: 934971-02-5
• Molecular Weight: 297.76
• Mol File: 934971-02-5.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (2R,3S)-1-chloro-3-amino-4-phenyl-2-butanol sulfuric acid salt(CAS DataBase Reference)
• NIST Chemistry Reference: (2R,3S)-1-chloro-3-amino-4-phenyl-2-butanol sulfuric acid salt(934971-02-5)
• EPA Substance Registry System: (2R,3S)-1-chloro-3-amino-4-phenyl-2-butanol sulfuric acid salt(934971-02-5)

Safety Data

• Hazardous Substances Data: 934971-02-5(Hazardous Substances Data)

Upstream product

• 111138-83-1 N,N-dibenzyl-L-phenylalanine benzyl ester 
• 63-91-2 L-phenylalanine 
• 934971-01-4 (2R,3S)-1-chloro-3-dibenzylamino-4-phenyl-2-butanol sulfuric acid salt 
• 171815-94-4 (3S)-3-dibenzylamino-1-chloro-2-oxo-4-phenylbutane 

Downstream Products

• 162536-40-5 (2R,3S)-1-Chloro-2-hydroxy-3-N-(tert-butoxycarbonyl)amino-4-phenylbutane 

Relevant articles and documents

A (2 R, 3 S) - 1 - chloro - 3 - tert-butoxy amide - 4 - phenyl - 2 - butanol preparation method

The invention provides a preparation method for (2R,3S)-1-chlorine-3-tert-butoxycarbonylamino-4-phenyl-2-butanol. The preparation method comprises the steps that L-phenylalanine is taken as raw materials, protected by adopting benzyl, esterified and then catalyzed through NMM to generate a mixed anhydride compound, the mixed anhydride compound reacts with diazomethane to generate diazoketone, a reduction reaction and palladium carbon reduction are performed, and finally the intermediate (2R,3S)-1-chlorine-3-tert-butoxycarbonylamino-4-phenyl-2-butanol is obtained. According to the preparation method, the low-cost benzyl is adopted to protect amidogen, the synthetic route is reasonable, the operation technology is simple, safe and high in yield, industrialization can be well achieved, and the production efficiency is improved.